Simulation scenario 7, HS phase

Setting description

Equal randomization: TC3 more effective in the HRD+ biomarker signature (cfr scen 4)

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4
all	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.022, shape = 1.3	scale = 0.024, shape = 1.3
all	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 41.8, median = 34.2	mean = 39, median = 31.9
all	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1.07, hr = 0.91	af = 1, hr = 1
HRD+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
HRD+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
HRD+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
TP53+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.023, shape = 1.3	scale = 0.024, shape = 1.3
TP53+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39.9, median = 32.6	mean = 39, median = 31.9
TP53+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1.02, hr = 0.97	af = 1, hr = 1
TEfus+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.022, shape = 1.3	scale = 0.024, shape = 1.3
TEfus+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 42.7, median = 34.8	mean = 39, median = 31.9
TEfus+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1.09, hr = 0.89	af = 1, hr = 1
PI3K+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.023, shape = 1.3	scale = 0.024, shape = 1.3
PI3K+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 40.5, median = 33.1	mean = 39, median = 31.9
PI3K+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1.04, hr = 0.95	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4
—-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
—-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
—-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
—+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
—+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
–+-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
–+-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
–++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
–++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+–	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
-+–	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+-+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
-+-+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-++-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
-++-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
-+++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
+—	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
+—	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
+–+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
+–+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
+–+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
+-+-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
+-+-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
+-+-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
+-++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
+-++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
+-++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
++–	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
++–	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
++–	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
++-+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
++-+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
++-+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
+++-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
+++-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
+++-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
++++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
++++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
++++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 all 3 9 75 20 HRD+ 1 2 83 8 TP53+ 4 7 41 36 TEfus+ 1 5 66 26 PI3K+ 5 6 45 21

TC1 TC2 TC3 TC4 all 0.006 0.018 0.150 0.040 HRD+ 0.002 0.004 0.166 0.016 TP53+ 0.008 0.014 0.082 0.072 TEfus+ 0.002 0.010 0.132 0.052 PI3K+ 0.010 0.012 0.090 0.042

futility (counts and proportions):

TC1 TC2 TC3 TC4 all 9 10 0 1 HRD+ 29 23 0 5 TP53+ 126 132 26 43 TEfus+ 92 93 2 18 PI3K+ 97 93 13 30

TC1 TC2 TC3 TC4 all 0.018 0.020 0.000 0.002 HRD+ 0.058 0.046 0.000 0.010 TP53+ 0.252 0.264 0.052 0.086 TEfus+ 0.184 0.186 0.004 0.036 PI3K+ 0.194 0.186 0.026 0.060

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

Operating characteristics

Characteristics	Overall	TC1	TC2	TC3	TC4
Error signature	0.478	0.028	0.05	0.304	0.194
Error subgroup	0.498	0.028	0.05	0.338	0.194
Power signature	0.166	0.000	0.00	0.166	0.000
Power subgroup	0.470	0.000	0.00	0.470	0.000

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4
all	graduation	0	3	9	75	20
all	futility	0	9	10	0	1
all	max_n	0	0	0	0	0
all	n	588 (564, 616)	305 (237, 367)	302 (238, 367)	308 (215, 356)	314 (254, 379)
all	n_unique	588 (564, 616)	305 (237, 367)	302 (238, 367)	308 (215, 356)	314 (254, 379)
all	time_trial	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (44, 60)	60 (60, 60)
all	time_stop	NA (NA, NA)	34 (11, 47)	29 (11, 52)	34 (12, 56)	26 (12, 51)
all	post_p	NA (NA, NA)	0.29 (0.05, 0.81)	0.36 (0.04, 0.8)	0.99 (0.83, 1)	0.87 (0.39, 1)
all	rate	0.023 (0.022, 0.025)	0.025 (0.023, 0.027)	0.024 (0.022, 0.027)	0.019 (0.017, 0.021)	0.021 (0.019, 0.023)
HRD+	graduation	0	1	2	83	8
HRD+	futility	0	29	23	0	5
HRD+	max_n	0	0	0	0	0
HRD+	n	86 (73, 98)	44 (34, 55)	44 (32, 54)	44 (28, 51)	45 (35, 57)
HRD+	n_unique	86 (73, 98)	44 (34, 55)	44 (32, 54)	44 (28, 51)	45 (35, 57)
HRD+	time_trial	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (58, 60)	60 (60, 60)
HRD+	time_stop	NA (NA, NA)	57 (52, 59)	56 (53, 60)	56 (47, 60)	54 (51, 57)
HRD+	post_p	NA (NA, NA)	0.37 (0.08, 0.82)	0.37 (0.08, 0.82)	1 (0.97, 1)	0.6 (0.2, 0.92)
HRD+	rate	0.023 (0.02, 0.028)	0.025 (0.019, 0.031)	0.024 (0.018, 0.031)	0.009 (0.006, 0.013)	0.021 (0.016, 0.027)
TP53+	graduation	0	4	7	41	36
TP53+	futility	0	126	132	26	43
TP53+	max_n	0	0	0	0	0
TP53+	n	219 (201, 237)	114 (56, 147)	112 (57, 151)	116 (59, 151)	119 (75, 158)
TP53+	n_unique	219 (201, 237)	114 (56, 147)	112 (57, 151)	116 (59, 151)	119 (75, 158)
TP53+	time_trial	60 (60, 60)	60 (31, 60)	60 (31, 60)	60 (49, 60)	60 (42, 60)
TP53+	time_stop	NA (NA, NA)	34 (24, 50)	38 (25, 53)	38 (28, 56)	39 (27, 55)
TP53+	post_p	NA (NA, NA)	0.36 (0.07, 0.82)	0.38 (0.06, 0.82)	0.81 (0.38, 0.98)	0.76 (0.28, 0.98)
TP53+	rate	0.023 (0.021, 0.026)	0.025 (0.021, 0.03)	0.025 (0.021, 0.029)	0.02 (0.017, 0.024)	0.021 (0.017, 0.025)
TEfus+	graduation	0	1	5	66	26
TEfus+	futility	0	92	93	2	18
TEfus+	max_n	0	0	0	0	0
TEfus+	n	193 (174, 208)	100 (60, 130)	98 (58, 127)	100 (56, 127)	104 (69, 136)
TEfus+	n_unique	193 (174, 208)	100 (60, 130)	98 (58, 127)	100 (56, 127)	104 (69, 136)
TEfus+	time_trial	60 (60, 60)	60 (41, 60)	60 (39, 60)	60 (49, 60)	60 (60, 60)
TEfus+	time_stop	NA (NA, NA)	41 (30, 55)	39 (30, 53)	41 (31, 57)	40 (29, 54)
TEfus+	post_p	NA (NA, NA)	0.39 (0.05, 0.84)	0.41 (0.06, 0.82)	0.92 (0.57, 1)	0.74 (0.33, 0.98)
TEfus+	rate	0.024 (0.021, 0.026)	0.025 (0.021, 0.03)	0.025 (0.021, 0.03)	0.018 (0.015, 0.022)	0.021 (0.017, 0.025)
PI3K+	graduation	0	5	6	45	21
PI3K+	futility	0	97	93	13	30
PI3K+	max_n	0	0	0	0	0
PI3K+	n	206 (188, 226)	107 (67, 138)	106 (64, 140)	108 (57, 139)	115 (76, 148)
PI3K+	n_unique	206 (188, 226)	107 (67, 138)	106 (64, 140)	108 (57, 139)	115 (76, 148)
PI3K+	time_trial	60 (60, 60)	60 (40, 60)	60 (41, 60)	60 (57, 60)	60 (60, 60)
PI3K+	time_stop	NA (NA, NA)	40 (28, 56)	41 (27, 55)	42 (28, 58)	38 (29, 52)
PI3K+	post_p	NA (NA, NA)	0.39 (0.06, 0.81)	0.38 (0.07, 0.81)	0.83 (0.39, 0.99)	0.76 (0.25, 0.98)
PI3K+	rate	0.024 (0.021, 0.026)	0.025 (0.021, 0.03)	0.025 (0.021, 0.029)	0.02 (0.017, 0.024)	0.021 (0.017, 0.026)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4
—-	graduation	0	3	9	75	20
—-	futility	0	9	10	0	1
—-	max_n	0	0	0	0	0
—-	n	176 (161, 194)	92 (78, 109)	93 (79, 107)	91 (65, 106)	91 (77, 107)
—-	n_unique	176 (161, 194)	92 (78, 109)	93 (79, 107)	91 (65, 106)	91 (77, 107)
—-	post_p	NA (NA, NA)	0.41 (0.07, 0.83)	0.38 (0.07, 0.83)	0.74 (0.27, 0.97)	0.74 (0.29, 0.96)
—-	rate	0.023 (0.021, 0.026)	0.025 (0.02, 0.029)	0.025 (0.02, 0.029)	0.021 (0.017, 0.025)	0.021 (0.017, 0.025)
—+	graduation	0	8	13	109	40
—+	futility	0	99	95	13	30
—+	max_n	0	0	0	0	0
—+	n	42 (33, 51)	22 (13, 30)	22 (13, 29)	22 (12, 29)	23 (14, 31)
—+	n_unique	42 (33, 51)	22 (13, 30)	22 (13, 29)	22 (12, 29)	23 (14, 31)
—+	post_p	NA (NA, NA)	0.46 (0.1, 0.81)	0.47 (0.12, 0.87)	0.59 (0.2, 0.91)	0.62 (0.23, 0.92)
—+	rate	0.023 (0.017, 0.03)	0.025 (0.017, 0.037)	0.024 (0.016, 0.035)	0.022 (0.014, 0.032)	0.021 (0.014, 0.03)
–+-	graduation	0	4	14	129	46
–+-	futility	0	95	97	2	19
–+-	max_n	0	0	0	0	0
–+-	n	13 (9, 19)	7 (3, 11)	7 (3, 11)	6 (2, 11)	7 (3, 11)
–+-	n_unique	13 (9, 19)	7 (3, 11)	7 (3, 11)	6 (2, 11)	7 (3, 11)
–+-	post_p	NA (NA, NA)	0.47 (0.18, 0.75)	0.48 (0.21, 0.76)	0.56 (0.28, 0.79)	0.53 (0.27, 0.82)
–+-	rate	0.024 (0.014, 0.037)	0.025 (0.011, 0.05)	0.024 (0.012, 0.047)	0.02 (0.008, 0.041)	0.021 (0.008, 0.042)
–++	graduation	0	8	18	149	63
–++	futility	0	153	154	15	43
–++	max_n	0	0	0	0	0
–++	n	62 (52, 72)	31 (18, 45)	31 (18, 44)	31 (16, 43)	33 (20, 47)
–++	n_unique	62 (52, 72)	31 (18, 45)	31 (18, 44)	31 (16, 43)	33 (20, 47)
–++	post_p	NA (NA, NA)	0.44 (0.1, 0.81)	0.43 (0.09, 0.82)	0.64 (0.24, 0.93)	0.62 (0.22, 0.93)
–++	rate	0.023 (0.019, 0.029)	0.025 (0.019, 0.034)	0.025 (0.018, 0.035)	0.021 (0.015, 0.028)	0.021 (0.015, 0.029)
-+–	graduation	0	7	15	104	55
-+–	futility	0	129	133	26	43
-+–	max_n	0	0	0	0	0
-+–	n	76 (66, 87)	39 (21, 54)	39 (21, 53)	40 (21, 54)	41 (25, 54)
-+–	n_unique	76 (66, 87)	39 (21, 54)	39 (21, 53)	40 (21, 54)	41 (25, 54)
-+–	post_p	NA (NA, NA)	0.41 (0.07, 0.84)	0.45 (0.11, 0.83)	0.66 (0.22, 0.92)	0.64 (0.2, 0.95)
-+–	rate	0.023 (0.019, 0.028)	0.025 (0.018, 0.033)	0.024 (0.019, 0.032)	0.021 (0.016, 0.028)	0.021 (0.015, 0.029)
-+-+	graduation	0	12	18	132	69
-+-+	futility	0	172	173	36	68
-+-+	max_n	0	0	0	0	0
-+-+	n	51 (41, 61)	26 (12, 36)	26 (13, 37)	27 (12, 38)	28 (14, 41)
-+-+	n_unique	51 (41, 61)	26 (12, 36)	26 (13, 37)	27 (12, 38)	28 (14, 41)
-+-+	post_p	NA (NA, NA)	0.44 (0.1, 0.83)	0.42 (0.11, 0.81)	0.58 (0.21, 0.91)	0.6 (0.21, 0.92)
-+-+	rate	0.023 (0.018, 0.029)	0.025 (0.017, 0.034)	0.025 (0.017, 0.034)	0.022 (0.014, 0.03)	0.021 (0.014, 0.03)
-++-	graduation	0	8	19	150	78
-++-	futility	0	180	183	28	57
-++-	max_n	0	0	0	0	0
-++-	n	45 (38, 54)	23 (11, 34)	23 (11, 34)	23 (12, 35)	25 (13, 37)
-++-	n_unique	45 (38, 54)	23 (11, 34)	23 (11, 34)	23 (12, 35)	25 (13, 37)
-++-	post_p	NA (NA, NA)	0.45 (0.11, 0.83)	0.45 (0.11, 0.82)	0.63 (0.25, 0.91)	0.62 (0.22, 0.92)
-++-	rate	0.024 (0.018, 0.03)	0.024 (0.017, 0.036)	0.025 (0.016, 0.037)	0.021 (0.013, 0.03)	0.021 (0.014, 0.03)
-+++	graduation	0	12	22	169	91
-+++	futility	0	210	213	38	79
-+++	max_n	0	0	0	0	0
-+++	n	36 (29, 43)	17 (8, 28)	17 (8, 28)	19 (8, 29)	20 (10, 31)
-+++	n_unique	36 (29, 43)	17 (8, 28)	17 (8, 28)	19 (8, 29)	20 (10, 31)
-+++	post_p	NA (NA, NA)	0.43 (0.12, 0.81)	0.45 (0.13, 0.81)	0.62 (0.25, 0.9)	0.63 (0.25, 0.91)
-+++	rate	0.024 (0.018, 0.031)	0.026 (0.017, 0.038)	0.025 (0.017, 0.037)	0.021 (0.013, 0.032)	0.021 (0.013, 0.031)
+—	graduation	0	4	11	154	27
+—	futility	0	38	33	0	6
+—	max_n	0	0	0	0	0
+—	n	40 (32, 49)	21 (15, 28)	21 (14, 27)	20 (12, 27)	21 (15, 28)
+—	n_unique	40 (32, 49)	21 (15, 28)	21 (14, 27)	20 (12, 27)	21 (15, 28)
+—	post_p	NA (NA, NA)	0.42 (0.1, 0.8)	0.4 (0.1, 0.78)	0.96 (0.78, 1)	0.53 (0.17, 0.87)
+—	rate	0.023 (0.017, 0.03)	0.024 (0.016, 0.034)	0.024 (0.016, 0.035)	0.009 (0.004, 0.015)	0.022 (0.014, 0.031)
+–+	graduation	0	9	15	181	47
+–+	futility	0	119	111	13	34
+–+	max_n	0	0	0	0	0
+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.51)
+–+	rate	0.038 (0.007, 0.053)	0 (0, 0.041)	0 (0, 0)	0 (0, 0)	0 (0, 0.16)
+-+-	graduation	0	5	16	204	53
+-+-	futility	0	120	117	2	24
+-+-	max_n	0	0	0	0	0
+-+-	n	28 (21, 36)	15 (8, 21)	14 (8, 21)	14 (7, 20)	15 (9, 21)
+-+-	n_unique	28 (21, 36)	15 (8, 21)	14 (8, 21)	14 (7, 20)	15 (9, 21)
+-+-	post_p	NA (NA, NA)	0.42 (0.1, 0.78)	0.41 (0.13, 0.77)	0.93 (0.67, 0.99)	0.54 (0.19, 0.87)
+-+-	rate	0.024 (0.016, 0.033)	0.024 (0.016, 0.038)	0.025 (0.014, 0.038)	0.008 (0.003, 0.016)	0.021 (0.012, 0.032)
+-++	graduation	0	9	20	218	70
+-++	futility	0	172	168	15	47
+-++	max_n	0	0	0	0	0
+-++	n	7 (3, 11)	3 (1, 7)	3 (1, 6)	3 (1, 6)	4 (1, 7)
+-++	n_unique	7 (3, 11)	3 (1, 7)	3 (1, 6)	3 (1, 6)	4 (1, 7)
+-++	post_p	NA (NA, NA)	0.47 (0.3, 0.65)	0.48 (0.3, 0.64)	0.59 (0.43, 0.82)	0.5 (0.33, 0.67)
+-++	rate	0.024 (0.008, 0.045)	0.024 (0, 0.064)	0.024 (0, 0.063)	0.008 (0, 0.034)	0.022 (0, 0.052)
++–	graduation	0	8	17	178	59
++–	futility	0	151	148	25	48
++–	max_n	0	0	0	0	0
++–	n	1 (0, 3)	0 (0, 2)	0 (0, 2)	0 (0, 2)	1 (0, 2)
++–	n_unique	1 (0, 3)	0 (0, 2)	0 (0, 2)	0 (0, 2)	1 (0, 2)
++–	post_p	NA (NA, NA)	0.48 (0.42, 0.56)	0.48 (0.42, 0.56)	0.53 (0.46, 0.58)	0.5 (0.43, 0.56)
++–	rate	0.019 (0, 0.071)	0.024 (0, 0.106)	0.024 (0, 0.122)	0 (0, 0.039)	0.014 (0, 0.094)
++-+	graduation	0	13	20	201	73
++-+	futility	0	188	184	35	72
++-+	max_n	0	0	0	0	0
++-+	n	9 (5, 13)	4 (1, 8)	4 (1, 8)	4 (1, 8)	5 (2, 9)
++-+	n_unique	9 (5, 13)	4 (1, 8)	4 (1, 8)	4 (1, 8)	5 (2, 9)
++-+	post_p	NA (NA, NA)	0.46 (0.27, 0.68)	0.46 (0.22, 0.71)	0.65 (0.47, 0.86)	0.5 (0.29, 0.71)
++-+	rate	0.023 (0.011, 0.04)	0.024 (0.008, 0.054)	0.025 (0.006, 0.055)	0.009 (0, 0.025)	0.021 (0.006, 0.056)
+++-	graduation	0	9	21	221	82
+++-	futility	0	199	195	27	62
+++-	max_n	0	0	0	0	0
+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
+++-	rate	0.064 (0, 0.278)	0.055 (0.051, 0.059)	0.018 (0, 0.051)	0.021 (0.021, 0.021)	0 (0, 0)
++++	graduation	0	13	24	235	95
++++	futility	0	225	222	37	83
++++	max_n	0	0	0	0	0
++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	post_p	NA (NA, NA)	0.48 (0.48, 0.48)	NA (NA, NA)	0.51 (0.51, 0.51)	0.48 (0.46, 0.5)
++++	rate	0 (0, 0.069)	0.044 (0, 0.261)	0.012 (0, 0.034)	0 (0, 0.039)	0 (0, 0.111)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4
all	count	3	9	75	20
all	time_stop	11 (10, 11)	23 (11, 52)	34 (12, 56)	26 (12, 52)
all	n_trt	54 (52, 58)	129 (55, 262)	174 (65, 300)	130 (59, 300)
all	n_control	104 (88, 123)	201 (92, 551)	336 (106, 545)	261 (114, 517)
all	post_p	0.96 (0.94, 0.97)	0.96 (0.91, 1)	0.99 (0.92, 1)	0.98 (0.89, 1)
all	order	1 (1, 1)	1 (1, 2.4)	1 (1, 2)	1 (1, 2.1)
HRD+	count	1	2	83	8
HRD+	time_stop	54 (54, 54)	59 (59, 59)	56 (47, 60)	52 (50, 57)
HRD+	n_trt	50 (50, 50)	50 (50, 50)	50 (50, 52)	52 (50, 54)
HRD+	n_control	83 (83, 83)	84 (83, 85)	79 (63, 95)	80 (69, 89)
HRD+	post_p	1 (1, 1)	0.97 (0.97, 0.98)	1 (0.98, 1)	0.98 (0.95, 0.99)
HRD+	order	7 (7, 7)	1.5 (1.1, 1.9)	1 (1, 2)	2 (1, 2.3)
TP53+	count	4	7	41	36
TP53+	time_stop	37 (28, 48)	49 (30, 53)	42 (30, 57)	42 (30, 57)
TP53+	n_trt	74 (54, 113)	76 (57, 108)	81 (52, 118)	86 (52, 122)
TP53+	n_control	132 (102, 186)	177 (110, 201)	151 (111, 201)	151 (104, 217)
TP53+	post_p	0.96 (0.93, 0.99)	0.96 (0.94, 0.99)	0.98 (0.94, 1)	0.98 (0.92, 1)
TP53+	order	1 (1, 1)	1 (1, 3.2)	1 (1, 3)	1 (1, 2)
TEfus+	count	1	5	66	26
TEfus+	time_stop	37 (37, 37)	39 (34, 48)	41 (30, 57)	42 (34, 55)
TEfus+	n_trt	51 (51, 51)	64 (56, 93)	68 (52, 95)	71 (52, 102)
TEfus+	n_control	119 (119, 119)	116 (98, 158)	130 (94, 174)	138 (98, 182)
TEfus+	post_p	0.97 (0.97, 0.97)	0.99 (0.96, 0.99)	0.99 (0.95, 1)	0.99 (0.94, 1)
TEfus+	order	1 (1, 1)	1 (1, 1)	1 (1, 3)	1 (1, 3)
PI3K+	count	5	6	45	21
PI3K+	time_stop	35 (28, 54)	46 (32, 56)	42 (30, 58)	40 (30, 55)
PI3K+	n_trt	54 (52, 96)	92 (58, 104)	69 (51, 110)	76 (51, 124)
PI3K+	n_control	121 (108, 178)	157 (103, 211)	144 (103, 202)	148 (88, 198)
PI3K+	post_p	0.97 (0.93, 1)	0.99 (0.97, 1)	0.99 (0.96, 1)	0.98 (0.95, 1)
PI3K+	order	1 (1, 1.6)	2.5 (1.5, 3.5)	2 (1, 3)	1 (1, 2)

Futility:

signature	var	TC1	TC2	TC3	TC4
all	count	9	10		1
all	time_stop	39 (23, 47)	30 (24, 50)		40 (40, 40)
all	n_trt	193 (116, 218)	168 (138, 228)		172 (172, 172)
all	n_control	389 (221, 491)	296 (233, 506)		398 (398, 398)
all	post_p	0.04 (0.01, 0.06)	0.02 (0, 0.07)		0.02 (0.02, 0.02)
all	order	2 (1, 3.4)	1.5 (1, 3.2)		3 (3, 3)
HRD+	count	29	23		5
HRD+	time_stop	57 (52, 59)	55 (53, 60)		54 (53, 58)
HRD+	n_trt	52 (50, 64)	51 (50, 52)		52 (50, 62)
HRD+	n_control	79 (67, 94)	79 (71, 90)		93 (72, 94)
HRD+	post_p	0.1 (0.01, 0.21)	0.1 (0.02, 0.26)		0.14 (0.07, 0.24)
HRD+	order	2 (1, 4)	3 (1, 4.8)		3 (3, 4)
TP53+	count	126	132	26	43
TP53+	time_stop	34 (24, 50)	38 (25, 53)	37 (26, 48)	36 (26, 52)
TP53+	n_trt	64 (51, 100)	68 (50, 113)	65 (52, 105)	69 (51, 112)
TP53+	n_control	122 (84, 181)	132 (84, 193)	130 (94, 182)	127 (92, 192)
TP53+	post_p	0.1 (0.02, 0.24)	0.09 (0.02, 0.24)	0.15 (0.04, 0.24)	0.13 (0.02, 0.26)
TP53+	order	1 (1, 2.5)	2 (1, 3)	1 (1, 3)	1 (1, 3)
TEfus+	count	92	93	2	18
TEfus+	time_stop	41 (30, 55)	39 (30, 54)	41 (35, 47)	37 (26, 47)
TEfus+	n_trt	64 (50, 93)	62 (51, 94)	66 (56, 75)	55 (50, 86)
TEfus+	n_control	124 (92, 168)	125 (91, 176)	137 (123, 151)	110 (75, 155)
TEfus+	post_p	0.08 (0.02, 0.22)	0.08 (0.01, 0.23)	0.2 (0.16, 0.23)	0.13 (0.02, 0.17)
TEfus+	order	2 (1, 3)	2 (1, 3.8)	1 (1, 1)	1 (1, 2)
PI3K+	count	97	93	13	30
PI3K+	time_stop	40 (28, 56)	40 (27, 55)	37 (25, 47)	35 (27, 50)
PI3K+	n_trt	73 (52, 108)	71 (51, 104)	61 (51, 86)	64 (52, 113)
PI3K+	n_control	140 (89, 190)	136 (87, 192)	109 (80, 179)	122 (90, 162)
PI3K+	post_p	0.09 (0.02, 0.24)	0.09 (0.02, 0.23)	0.08 (0.04, 0.21)	0.12 (0.02, 0.28)
PI3K+	order	2 (1, 4)	2 (1, 4)	1 (1, 3)	1 (1, 4)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
all	TC1	time	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)	11 (10, 11)
all	TC1	n	15 (13, 17)	3 (2, 5)	1 (0, 2)	6 (5, 7)	6 (4, 9)	6 (5, 7)	4 (3, 5)	3 (2, 6)	5 (3, 5)	0 (0, 0)	3 (1, 3)	1 (0, 2)	0 (0, 0)	1 (0, 1)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.62 (0.61, 0.62)	0.52 (0.51, 0.58)	0.52 (0.52, 0.52)	0.52 (0.51, 0.54)	0.55 (0.54, 0.67)	0.58 (0.54, 0.58)	0.56 (0.54, 0.57)	0.52 (0.5, 0.54)	0.5 (0.5, 0.54)	NA (NA, NA)	0.53 (0.52, 0.53)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.014 (0.003, 0.015)	0 (0, 0.051)	0 (0, 0)	0 (0, 0)	0 (0, 0.03)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0.361 (0.072, 0.65)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	9	9	9	9	9	9	9	9	9	9	9	9	9	9	9	9
all	TC2	time	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)	23 (11, 52)
all	TC2	n	35 (16, 77)	11 (2, 21)	2 (0, 5)	13 (4, 28)	13 (6, 37)	10 (4, 17)	5 (2, 19)	6 (3, 18)	7 (4, 17)	0 (0, 0)	5 (1, 14)	2 (0, 3)	0 (0, 0)	1 (0, 3)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.7 (0.55, 0.93)	0.64 (0.51, 0.78)	0.56 (0.51, 0.63)	0.64 (0.57, 0.82)	0.57 (0.53, 0.67)	0.55 (0.51, 0.63)	0.53 (0.52, 0.61)	0.57 (0.52, 0.88)	0.57 (0.51, 0.66)	NA (NA, NA)	0.53 (0.51, 0.66)	0.52 (0.5, 0.56)	NA (NA, NA)	0.54 (0.53, 0.65)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.01 (0, 0.021)	0.006 (0, 0.024)	0 (0, 0.03)	0.01 (0, 0.018)	0.012 (0, 0.021)	0.007 (0, 0.02)	0.007 (0, 0.019)	0 (0, 0.016)	0 (0, 0.016)	NA (NA, NA)	0 (0, 0.018)	0.009 (0, 0.052)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	75	75	75	75	75	75	75	75	75	75	75	75	75	75	75	75
all	TC3	time	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)	34 (12, 56)
all	TC3	n	53 (18, 92)	13 (4, 23)	4 (0, 8)	17 (6, 31)	22 (10, 37)	16 (4, 28)	13 (6, 26)	9 (4, 19)	11 (4, 19)	0 (0, 0)	7 (2, 16)	2 (0, 5)	0 (0, 1)	2 (0, 6)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.69 (0.54, 0.95)	0.6 (0.53, 0.82)	0.56 (0.51, 0.8)	0.61 (0.52, 0.89)	0.6 (0.52, 0.91)	0.62 (0.51, 0.89)	0.59 (0.51, 0.84)	0.57 (0.51, 0.83)	0.66 (0.54, 0.96)	NA (NA, NA)	0.7 (0.53, 0.95)	0.55 (0.51, 0.65)	0.53 (0.52, 0.61)	0.55 (0.51, 0.72)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.016 (0.007, 0.022)	0.013 (0, 0.024)	0.007 (0, 0.019)	0.014 (0, 0.021)	0.015 (0, 0.023)	0.016 (0, 0.022)	0.015 (0, 0.023)	0.012 (0, 0.023)	0.007 (0, 0.016)	NA (NA, NA)	0.002 (0, 0.013)	0 (0, 0.022)	0 (0, 0.025)	0 (0, 0.02)	0 (0, 0)	0.011 (0, 0.378)
all	TC4	count	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20
all	TC4	time	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)	26 (12, 52)
all	TC4	n	40 (17, 96)	8 (1, 17)	3 (1, 8)	12 (4, 31)	22 (9, 39)	14 (4, 26)	10 (4, 25)	10 (2, 22)	9 (4, 21)	0 (0, 0)	7 (2, 17)	1 (0, 4)	0 (0, 1)	3 (0, 6)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.72 (0.53, 0.9)	0.61 (0.52, 0.77)	0.55 (0.51, 0.6)	0.58 (0.52, 0.78)	0.59 (0.51, 0.91)	0.61 (0.53, 0.73)	0.55 (0.51, 0.74)	0.63 (0.52, 0.8)	0.55 (0.51, 0.77)	NA (NA, NA)	0.56 (0.51, 0.82)	0.56 (0.52, 0.59)	0.52 (0.51, 0.54)	0.55 (0.51, 0.62)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.016 (0.008, 0.022)	0.006 (0, 0.02)	0 (0, 0.02)	0.012 (0, 0.023)	0.014 (0, 0.023)	0.013 (0, 0.021)	0.014 (0, 0.02)	0.009 (0, 0.021)	0.011 (0, 0.021)	NA (NA, NA)	0.008 (0, 0.018)	0.01 (0, 0.026)	0 (0, 0.008)	0 (0, 0.017)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									1	1	1	1	1	1	1	1
HRD+	TC1	time									54 (54, 54)	54 (54, 54)	54 (54, 54)	54 (54, 54)	54 (54, 54)	54 (54, 54)	54 (54, 54)	54 (54, 54)
HRD+	TC1	n									25 (25, 25)	0 (0, 0)	17 (17, 17)	5 (5, 5)	1 (1, 1)	2 (2, 2)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.92 (0.92, 0.92)	NA (NA, NA)	0.7 (0.7, 0.7)	0.95 (0.95, 0.95)	0.55 (0.55, 0.55)	0.58 (0.58, 0.58)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.013 (0.013, 0.013)	NA (NA, NA)	0.021 (0.021, 0.021)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									2	2	2	2	2	2	2	2
HRD+	TC2	time									59 (59, 59)	59 (59, 59)	59 (59, 59)	59 (59, 59)	59 (59, 59)	59 (59, 59)	59 (59, 59)	59 (59, 59)
HRD+	TC2	n									25 (24, 26)	0 (0, 0)	16 (15, 17)	7 (6, 8)	0 (0, 1)	2 (0, 3)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.82 (0.8, 0.83)	NA (NA, NA)	0.84 (0.82, 0.86)	0.67 (0.55, 0.78)	0.52 (0.52, 0.52)	0.77 (0.77, 0.77)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.016 (0.015, 0.018)	NA (NA, NA)	0.012 (0.01, 0.013)	0.03 (0.025, 0.035)	0 (0, 0)	0.008 (0.008, 0.008)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									83	83	83	83	83	83	83	83
HRD+	TC3	time									56 (47, 60)	56 (47, 60)	56 (47, 60)	56 (47, 60)	56 (47, 60)	56 (47, 60)	56 (47, 60)	56 (47, 60)
HRD+	TC3	n									23 (18, 29)	0 (0, 0)	17 (11, 22)	4 (2, 7)	1 (0, 2)	5 (3, 9)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.97 (0.77, 1)	NA (NA, NA)	0.94 (0.79, 0.99)	0.62 (0.53, 0.81)	0.53 (0.5, 0.58)	0.65 (0.52, 0.87)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.008 (0.004, 0.014)	NA (NA, NA)	0.007 (0.003, 0.014)	0.006 (0, 0.015)	0 (0, 0.019)	0.008 (0, 0.018)	NA (NA, NA)	0.265 (0.053, 0.477)
HRD+	TC4	count									8	8	8	8	8	8	8	8
HRD+	TC4	time									52 (50, 57)	52 (50, 57)	52 (50, 57)	52 (50, 57)	52 (50, 57)	52 (50, 57)	52 (50, 57)	52 (50, 57)
HRD+	TC4	n									22 (17, 27)	0 (0, 0)	19 (15, 21)	4 (3, 9)	0 (0, 1)	6 (3, 10)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.81 (0.7, 0.9)	NA (NA, NA)	0.84 (0.75, 0.94)	0.59 (0.51, 0.62)	NA (NA, NA)	0.68 (0.52, 0.8)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.016 (0.013, 0.021)	NA (NA, NA)	0.013 (0.011, 0.015)	0.015 (0, 0.027)	0 (0, 0)	0.012 (0.005, 0.024)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					4	4	4	4					4	4	4	4
TP53+	TC1	time					37 (28, 48)	37 (28, 48)	37 (28, 48)	37 (28, 48)					37 (28, 48)	37 (28, 48)	37 (28, 48)	37 (28, 48)
TP53+	TC1	n					28 (21, 43)	18 (11, 28)	15 (11, 21)	12 (8, 17)					0 (0, 1)	2 (0, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.71 (0.7, 0.89)	0.83 (0.65, 0.87)	0.72 (0.59, 0.76)	0.81 (0.8, 0.9)					0.5 (0.5, 0.5)	0.52 (0.52, 0.56)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.012 (0.009, 0.014)	0.013 (0.009, 0.016)	0.013 (0.007, 0.014)	0.012 (0.003, 0.013)					0 (0, 0)	0.016 (0.003, 0.024)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					7	7	7	7					7	7	7	7
TP53+	TC2	time					49 (30, 53)	49 (30, 53)	49 (30, 53)	49 (30, 53)					49 (30, 53)	49 (30, 53)	49 (30, 53)	49 (30, 53)
TP53+	TC2	n					30 (22, 36)	15 (9, 26)	19 (8, 25)	16 (7, 21)					0 (0, 1)	2 (0, 9)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.73 (0.71, 0.76)	0.78 (0.66, 0.93)	0.77 (0.6, 0.85)	0.73 (0.52, 0.76)					0.57 (0.56, 0.58)	0.54 (0.54, 0.56)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.019 (0.015, 0.024)	0.018 (0.008, 0.021)	0.014 (0.011, 0.025)	0.021 (0.01, 0.025)					0 (0, 0)	0 (0, 0.016)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					41	41	41	41					41	41	41	41
TP53+	TC3	time					42 (30, 57)	42 (30, 57)	42 (30, 57)	42 (30, 57)					42 (30, 57)	42 (30, 57)	42 (30, 57)	42 (30, 57)
TP53+	TC3	n					27 (18, 43)	18 (10, 28)	16 (11, 24)	13 (6, 24)					0 (0, 2)	4 (1, 7)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.8 (0.72, 0.94)	0.73 (0.66, 0.84)	0.78 (0.7, 0.88)	0.74 (0.53, 0.92)					0.54 (0.5, 0.63)	0.58 (0.53, 0.72)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.015 (0.009, 0.021)	0.016 (0.008, 0.019)	0.013 (0.005, 0.021)	0.013 (0.007, 0.022)					0 (0, 0)	0 (0, 0.013)	0 (0, 0)	NA (NA, NA)
TP53+	TC4	count					36	36	36	36					36	36	36	36
TP53+	TC4	time					42 (30, 57)	42 (30, 57)	42 (30, 57)	42 (30, 57)					42 (30, 57)	42 (30, 57)	42 (30, 57)	42 (30, 57)
TP53+	TC4	n					29 (22, 46)	20 (10, 29)	17 (9, 24)	16 (7, 22)					0 (0, 2)	4 (2, 8)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.81 (0.71, 0.96)	0.77 (0.71, 0.94)	0.78 (0.59, 0.92)	0.75 (0.55, 0.93)					0.54 (0.51, 0.6)	0.55 (0.51, 0.67)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.016 (0.01, 0.019)	0.014 (0.006, 0.019)	0.016 (0.009, 0.021)	0.014 (0.004, 0.019)					0 (0, 0.03)	0.013 (0, 0.029)	NA (NA, NA)	0.113 (0.113, 0.113)
TEfus+	TC1	count			1	1			1	1			1	1			1	1
TEfus+	TC1	time			37 (37, 37)	37 (37, 37)			37 (37, 37)	37 (37, 37)			37 (37, 37)	37 (37, 37)			37 (37, 37)	37 (37, 37)
TEfus+	TC1	n			6 (6, 6)	16 (16, 16)			15 (15, 15)	10 (10, 10)			4 (4, 4)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.56 (0.56, 0.56)	0.73 (0.73, 0.73)			0.82 (0.82, 0.82)	0.87 (0.87, 0.87)			0.56 (0.56, 0.56)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.18 (0.18, 0.18)	0.07 (0.07, 0.07)			0.12 (0.12, 0.12)	0.06 (0.06, 0.06)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.019 (0.019, 0.019)	0.016 (0.016, 0.016)			0.011 (0.011, 0.011)	0 (0, 0)			0.014 (0.014, 0.014)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			5	5			5	5			5	5			5	5
TEfus+	TC2	time			39 (34, 48)	39 (34, 48)			39 (34, 48)	39 (34, 48)			39 (34, 48)	39 (34, 48)			39 (34, 48)	39 (34, 48)
TEfus+	TC2	n			5 (4, 7)	18 (16, 34)			19 (12, 24)	12 (9, 18)			9 (7, 10)	6 (1, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.55 (0.52, 0.64)	0.89 (0.74, 0.91)			0.77 (0.6, 0.81)	0.7 (0.61, 0.88)			0.58 (0.53, 0.73)	0.54 (0.52, 0.56)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.009 (0.007, 0.016)	0.013 (0.008, 0.02)			0.017 (0.009, 0.019)	0.01 (0.009, 0.022)			0.014 (0.004, 0.02)	0.014 (0.004, 0.019)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	count			66	66			66	66			66	66			66	66
TEfus+	TC3	time			41 (30, 57)	41 (30, 57)			41 (30, 57)	41 (30, 57)			41 (30, 57)	41 (30, 57)			41 (30, 57)	41 (30, 57)
TEfus+	TC3	n			4 (2, 9)	22 (14, 32)			16 (11, 25)	13 (8, 20)			10 (6, 17)	2 (0, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.58 (0.51, 0.77)	0.76 (0.71, 0.94)			0.78 (0.7, 0.89)	0.76 (0.59, 0.89)			0.81 (0.57, 0.97)	0.55 (0.52, 0.71)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.012 (0, 0.023)	0.014 (0.008, 0.02)			0.016 (0.005, 0.019)	0.012 (0.006, 0.022)			0.007 (0, 0.015)	0 (0, 0.021)			NA (NA, NA)	0 (0, 0)
TEfus+	TC4	count			26	26			26	26			26	26			26	26
TEfus+	TC4	time			42 (34, 55)	42 (34, 55)			42 (34, 55)	42 (34, 55)			42 (34, 55)	42 (34, 55)			42 (34, 55)	42 (34, 55)
TEfus+	TC4	n			6 (1, 8)	23 (16, 34)			18 (10, 28)	14 (8, 22)			9 (6, 14)	3 (1, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.59 (0.51, 0.79)	0.82 (0.72, 0.96)			0.77 (0.65, 0.96)	0.76 (0.6, 0.88)			0.65 (0.52, 0.9)	0.54 (0.51, 0.62)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.014 (0, 0.023)	0.014 (0.009, 0.021)			0.014 (0.007, 0.019)	0.013 (0.007, 0.019)			0.012 (0.005, 0.02)	0 (0, 0.022)			NA (NA, NA)	0 (0, 0)
PI3K+	TC1	count		5		5		5		5		5		5		5		5
PI3K+	TC1	time		35 (28, 54)		35 (28, 54)		35 (28, 54)		35 (28, 54)		35 (28, 54)		35 (28, 54)		35 (28, 54)		35 (28, 54)
PI3K+	TC1	n		13 (7, 17)		21 (15, 26)		19 (10, 28)		10 (8, 20)		0 (0, 0)		1 (0, 4)		3 (1, 4)		0 (0, 0)
PI3K+	TC1	post_p		0.74 (0.64, 0.84)		0.82 (0.75, 0.91)		0.77 (0.61, 0.84)		0.61 (0.54, 0.9)		NA (NA, NA)		0.53 (0.53, 0.57)		0.59 (0.54, 0.62)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.01 (0.003, 0.018)		0.017 (0.004, 0.021)		0.014 (0.01, 0.02)		0.017 (0.005, 0.027)		NA (NA, NA)		0 (0, 0.009)		0.007 (0, 0.02)		NA (NA, NA)
PI3K+	TC2	count		6		6		6		6		6		6		6		6
PI3K+	TC2	time		46 (32, 56)		46 (32, 56)		46 (32, 56)		46 (32, 56)		46 (32, 56)		46 (32, 56)		46 (32, 56)		46 (32, 56)
PI3K+	TC2	n		20 (14, 28)		29 (16, 38)		14 (12, 24)		16 (12, 19)		0 (0, 0)		2 (1, 3)		2 (0, 4)		0 (0, 0)
PI3K+	TC2	post_p		0.75 (0.65, 0.83)		0.82 (0.75, 0.9)		0.84 (0.7, 0.93)		0.78 (0.74, 0.91)		NA (NA, NA)		0.51 (0.5, 0.52)		0.56 (0.53, 0.58)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.016 (0.01, 0.022)		0.016 (0.01, 0.02)		0.013 (0.012, 0.021)		0.018 (0.014, 0.027)		NA (NA, NA)		0.008 (0, 0.023)		0.003 (0, 0.027)		NA (NA, NA)
PI3K+	TC3	count		45		45		45		45		45		45		45		45
PI3K+	TC3	time		42 (30, 58)		42 (30, 58)		42 (30, 58)		42 (30, 58)		42 (30, 58)		42 (30, 58)		42 (30, 58)		42 (30, 58)
PI3K+	TC3	n		16 (10, 26)		21 (14, 35)		18 (10, 31)		12 (8, 22)		0 (0, 0)		2 (0, 5)		3 (1, 7)		0 (0, 0)
PI3K+	TC3	post_p		0.74 (0.69, 0.91)		0.79 (0.71, 0.9)		0.76 (0.62, 0.94)		0.74 (0.58, 0.91)		NA (NA, NA)		0.56 (0.52, 0.66)		0.57 (0.53, 0.73)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.014 (0.006, 0.02)		0.015 (0.008, 0.019)		0.015 (0.008, 0.022)		0.013 (0.006, 0.02)		NA (NA, NA)		0 (0, 0.024)		0 (0, 0.017)		0 (0, 0)
PI3K+	TC4	count		21		21		21		21		21		21		21		21
PI3K+	TC4	time		40 (30, 55)		40 (30, 55)		40 (30, 55)		40 (30, 55)		40 (30, 55)		40 (30, 55)		40 (30, 55)		40 (30, 55)
PI3K+	TC4	n		15 (9, 24)		21 (16, 37)		22 (10, 35)		16 (5, 23)		0 (0, 0)		2 (1, 6)		4 (2, 7)		0 (0, 0)
PI3K+	TC4	post_p		0.75 (0.58, 0.94)		0.77 (0.72, 0.94)		0.78 (0.72, 0.91)		0.76 (0.62, 0.9)		NA (NA, NA)		0.55 (0.51, 0.6)		0.54 (0.51, 0.64)		NA (NA, NA)
PI3K+	TC4	r_prob		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.31 (0.31, 0.31)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.015 (0.008, 0.019)		0.012 (0.007, 0.019)		0.013 (0.008, 0.02)		0.013 (0, 0.016)		NA (NA, NA)		0.005 (0, 0.035)		0.011 (0, 0.024)		NA (NA, NA)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	9	9	9	9	9	9	9	9	9	9	9	9	9	9	9	9
all	TC1	time	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)	39 (23, 47)
all	TC1	n	59 (36, 72)	16 (8, 21)	3 (2, 4)	16 (9, 28)	23 (12, 29)	13 (9, 17)	11 (7, 15)	9 (5, 14)	11 (6, 16)	0 (0, 0)	12 (6, 15)	2 (1, 4)	0 (0, 1)	2 (1, 4)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.32 (0.14, 0.43)	0.31 (0.17, 0.38)	0.38 (0.27, 0.46)	0.43 (0.33, 0.45)	0.36 (0.23, 0.47)	0.3 (0.1, 0.4)	0.41 (0.26, 0.48)	0.38 (0.17, 0.5)	0.42 (0.13, 0.49)	NA (NA, NA)	0.41 (0.19, 0.45)	0.45 (0.35, 0.49)	0.46 (0.44, 0.49)	0.48 (0.29, 0.49)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.023 (0.021, 0.029)	0.029 (0.021, 0.035)	0.041 (0.03, 0.055)	0.023 (0.02, 0.029)	0.025 (0.021, 0.047)	0.028 (0.024, 0.039)	0.023 (0.019, 0.033)	0.028 (0.015, 0.044)	0.027 (0.018, 0.032)	NA (NA, NA)	0.029 (0.022, 0.035)	0.036 (0.015, 0.885)	0.082 (0.016, 0.244)	0.03 (0.007, 0.167)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10
all	TC2	time	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)	30 (24, 50)
all	TC2	n	49 (40, 74)	13 (10, 15)	5 (0, 10)	19 (9, 29)	23 (16, 32)	10 (7, 20)	12 (7, 19)	8 (4, 15)	14 (5, 20)	0 (0, 0)	8 (4, 14)	2 (0, 4)	0 (0, 2)	2 (1, 7)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.21 (0.07, 0.49)	0.36 (0.11, 0.49)	0.44 (0.29, 0.46)	0.27 (0.16, 0.44)	0.3 (0.17, 0.38)	0.35 (0.08, 0.48)	0.38 (0.22, 0.5)	0.46 (0.31, 0.49)	0.28 (0.16, 0.45)	NA (NA, NA)	0.28 (0.13, 0.47)	0.48 (0.36, 0.49)	0.46 (0.45, 0.49)	0.43 (0.32, 0.49)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.025 (0.02, 0.028)	0.032 (0.019, 0.053)	0.032 (0.024, 0.076)	0.03 (0.02, 0.041)	0.03 (0.022, 0.041)	0.034 (0.019, 0.042)	0.027 (0.018, 0.038)	0.023 (0.009, 0.037)	0.031 (0.024, 0.051)	NA (NA, NA)	0.037 (0.028, 0.066)	0.026 (0.009, 0.177)	0.013 (0, 0.247)	0.039 (0, 0.233)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC4	time	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)
all	TC4	n	64 (64, 64)	15 (15, 15)	2 (2, 2)	17 (17, 17)	24 (24, 24)	11 (11, 11)	8 (8, 8)	7 (7, 7)	16 (16, 16)	0 (0, 0)	7 (7, 7)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.05 (0.05, 0.05)	0.17 (0.17, 0.17)	0.45 (0.45, 0.45)	0.46 (0.46, 0.46)	0.41 (0.41, 0.41)	0.38 (0.38, 0.38)	0.28 (0.28, 0.28)	0.45 (0.45, 0.45)	0.45 (0.45, 0.45)	NA (NA, NA)	0.28 (0.28, 0.28)	NA (NA, NA)	NA (NA, NA)	0.45 (0.45, 0.45)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.028 (0.028, 0.028)	0.036 (0.036, 0.036)	0.086 (0.086, 0.086)	0.02 (0.02, 0.02)	0.025 (0.025, 0.025)	0.024 (0.024, 0.024)	0.034 (0.034, 0.034)	0.021 (0.021, 0.021)	0.022 (0.022, 0.022)	NA (NA, NA)	0.037 (0.037, 0.037)	NA (NA, NA)	NA (NA, NA)	0.119 (0.119, 0.119)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									29	29	29	29	29	29	29	29
HRD+	TC1	time									57 (52, 59)	57 (52, 59)	57 (52, 59)	57 (52, 59)	57 (52, 59)	57 (52, 59)	57 (52, 59)	57 (52, 59)
HRD+	TC1	n									25 (18, 30)	0 (0, 0)	18 (14, 23)	4 (1, 8)	0 (0, 2)	6 (3, 10)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.2 (0.11, 0.36)	NA (NA, NA)	0.24 (0.05, 0.44)	0.44 (0.34, 0.49)	0.48 (0.44, 0.49)	0.38 (0.22, 0.48)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.027 (0.023, 0.035)	NA (NA, NA)	0.028 (0.022, 0.042)	0.033 (0.02, 0.063)	0.04 (0, 0.121)	0.03 (0.02, 0.056)	NA (NA, NA)	0.271 (0.271, 0.271)
HRD+	TC2	count									23	23	23	23	23	23	23	23
HRD+	TC2	time									55 (53, 60)	55 (53, 60)	55 (53, 60)	55 (53, 60)	55 (53, 60)	55 (53, 60)	55 (53, 60)	55 (53, 60)
HRD+	TC2	n									23 (17, 30)	0 (0, 0)	19 (14, 25)	4 (2, 6)	0 (0, 1)	5 (3, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.29 (0.15, 0.47)	NA (NA, NA)	0.22 (0.09, 0.48)	0.44 (0.3, 0.49)	0.46 (0.44, 0.49)	0.35 (0.23, 0.47)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.026 (0.02, 0.035)	0 (0, 0)	0.028 (0.019, 0.038)	0.028 (0.017, 0.082)	0.058 (0, 0.268)	0.031 (0.019, 0.057)	NA (NA, NA)	0 (0, 0)
HRD+	TC4	count									5	5	5	5	5	5	5	5
HRD+	TC4	time									54 (53, 58)	54 (53, 58)	54 (53, 58)	54 (53, 58)	54 (53, 58)	54 (53, 58)	54 (53, 58)	54 (53, 58)
HRD+	TC4	n									24 (18, 27)	0 (0, 0)	21 (15, 28)	3 (2, 6)	0 (0, 2)	6 (2, 10)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.2 (0.09, 0.44)	NA (NA, NA)	0.4 (0.19, 0.5)	0.45 (0.42, 0.49)	NA (NA, NA)	0.38 (0.23, 0.47)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.03 (0.021, 0.036)	NA (NA, NA)	0.023 (0.015, 0.03)	0.04 (0.019, 0.067)	0.028 (0.028, 0.028)	0.028 (0.019, 0.041)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					126	126	126	126					126	126	126	126
TP53+	TC1	time					34 (24, 50)	34 (24, 50)	34 (24, 50)	34 (24, 50)					34 (24, 50)	34 (24, 50)	34 (24, 50)	34 (24, 50)
TP53+	TC1	n					23 (16, 38)	14 (9, 23)	14 (9, 22)	11 (7, 17)					0 (0, 2)	3 (0, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.31 (0.08, 0.46)	0.37 (0.17, 0.48)	0.39 (0.16, 0.48)	0.38 (0.18, 0.48)					0.45 (0.41, 0.48)	0.46 (0.38, 0.5)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.027 (0.019, 0.037)	0.026 (0.019, 0.041)	0.027 (0.019, 0.04)	0.028 (0.019, 0.042)					0.039 (0, 0.347)	0.029 (0, 0.091)	0 (0, 0)	NA (NA, NA)
TP53+	TC2	count					132	132	132	132					132	132	132	132
TP53+	TC2	time					38 (25, 53)	38 (25, 53)	38 (25, 53)	38 (25, 53)					38 (25, 53)	38 (25, 53)	38 (25, 53)	38 (25, 53)
TP53+	TC2	n					25 (16, 38)	16 (10, 27)	15 (9, 24)	12 (7, 20)					0 (0, 1)	3 (0, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.35 (0.11, 0.48)	0.37 (0.13, 0.48)	0.34 (0.14, 0.48)	0.38 (0.11, 0.48)					0.45 (0.41, 0.49)	0.44 (0.31, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.025 (0.02, 0.033)	0.026 (0.018, 0.037)	0.027 (0.02, 0.041)	0.027 (0.018, 0.044)					0.027 (0, 0.234)	0.033 (0, 0.1)	0 (0, 0)	0 (0, 0)
TP53+	TC3	count					26	26	26	26					26	26	26	26
TP53+	TC3	time					37 (26, 48)	37 (26, 48)	37 (26, 48)	37 (26, 48)					37 (26, 48)	37 (26, 48)	37 (26, 48)	37 (26, 48)
TP53+	TC3	n					22 (16, 36)	17 (10, 30)	14 (8, 22)	11 (6, 18)					0 (0, 1)	3 (0, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.32 (0.18, 0.45)	0.41 (0.3, 0.47)	0.39 (0.2, 0.49)	0.38 (0.24, 0.46)					0.48 (0.48, 0.49)	0.47 (0.41, 0.5)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.027 (0.019, 0.037)	0.024 (0.02, 0.038)	0.023 (0.019, 0.036)	0.026 (0.021, 0.038)					0 (0, 0)	0.017 (0.001, 0.052)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					43	43	43	43					43	43	43	43
TP53+	TC4	time					36 (26, 52)	36 (26, 52)	36 (26, 52)	36 (26, 52)					36 (26, 52)	36 (26, 52)	36 (26, 52)	36 (26, 52)
TP53+	TC4	n					25 (17, 38)	16 (9, 28)	15 (8, 22)	11 (6, 20)					0 (0, 1)	3 (0, 4)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.36 (0.17, 0.47)	0.36 (0.16, 0.48)	0.38 (0.19, 0.48)	0.41 (0.19, 0.49)					0.48 (0.47, 0.48)	0.45 (0.38, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.024 (0.02, 0.032)	0.027 (0.02, 0.037)	0.027 (0.019, 0.036)	0.025 (0.018, 0.033)					0.011 (0, 0.073)	0.032 (0.016, 0.096)	NA (NA, NA)	0 (0, 0)
TEfus+	TC1	count			92	92			92	92			92	92			92	92
TEfus+	TC1	time			41 (30, 55)	41 (30, 55)			41 (30, 55)	41 (30, 55)			41 (30, 55)	41 (30, 55)			41 (30, 55)	41 (30, 55)
TEfus+	TC1	n			4 (2, 8)	22 (13, 33)			15 (10, 24)	11 (6, 18)			10 (5, 18)	2 (1, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.43 (0.32, 0.49)	0.3 (0.07, 0.46)			0.34 (0.16, 0.46)	0.34 (0.15, 0.47)			0.37 (0.21, 0.47)	0.46 (0.35, 0.5)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.18 (0.18, 0.18)	0.07 (0.07, 0.07)			0.12 (0.12, 0.12)	0.06 (0.06, 0.06)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.031 (0.02, 0.075)	0.027 (0.021, 0.036)			0.027 (0.02, 0.036)	0.029 (0.021, 0.048)			0.028 (0.019, 0.041)	0.03 (0, 0.137)			0.06 (0.06, 0.06)	0.271 (0.271, 0.271)
TEfus+	TC2	count			93	93			93	93			93	93			93	93
TEfus+	TC2	time			39 (30, 54)	39 (30, 54)			39 (30, 54)	39 (30, 54)			39 (30, 54)	39 (30, 54)			39 (30, 54)	39 (30, 54)
TEfus+	TC2	n			5 (2, 9)	21 (16, 32)			15 (9, 24)	11 (7, 19)			9 (5, 16)	3 (0, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.43 (0.3, 0.49)	0.28 (0.1, 0.47)			0.34 (0.1, 0.48)	0.34 (0.13, 0.46)			0.37 (0.15, 0.49)	0.45 (0.35, 0.49)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.033 (0.018, 0.065)	0.026 (0.02, 0.036)			0.027 (0.018, 0.039)	0.029 (0.02, 0.046)			0.03 (0.018, 0.049)	0.035 (0.014, 0.111)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	count			2	2			2	2			2	2			2	2
TEfus+	TC3	time			41 (35, 47)	41 (35, 47)			41 (35, 47)	41 (35, 47)			41 (35, 47)	41 (35, 47)			41 (35, 47)	41 (35, 47)
TEfus+	TC3	n			4 (3, 4)	22 (19, 24)			16 (14, 18)	10 (5, 14)			10 (9, 11)	5 (5, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.34 (0.23, 0.44)	0.44 (0.4, 0.48)			0.39 (0.36, 0.43)	0.37 (0.27, 0.47)			0.42 (0.42, 0.43)	0.41 (0.38, 0.44)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.034 (0.034, 0.035)	0.023 (0.022, 0.024)			0.024 (0.023, 0.024)	0.024 (0.016, 0.032)			0.015 (0.014, 0.016)	0.031 (0.023, 0.039)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			18	18			18	18			18	18			18	18
TEfus+	TC4	time			37 (26, 47)	37 (26, 47)			37 (26, 47)	37 (26, 47)			37 (26, 47)	37 (26, 47)			37 (26, 47)	37 (26, 47)
TEfus+	TC4	n			4 (2, 7)	18 (14, 27)			14 (9, 24)	11 (6, 15)			10 (6, 14)	2 (0, 3)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.44 (0.39, 0.48)	0.33 (0.13, 0.42)			0.41 (0.28, 0.48)	0.36 (0.22, 0.46)			0.37 (0.23, 0.44)	0.42 (0.38, 0.48)			NA (NA, NA)	0.47 (0.47, 0.47)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.029 (0.017, 0.052)	0.026 (0.018, 0.032)			0.023 (0.014, 0.029)	0.028 (0.02, 0.038)			0.031 (0.018, 0.046)	0.071 (0.011, 0.164)			NA (NA, NA)	0.052 (0.01, 0.093)
PI3K+	TC1	count		97		97		97		97		97		97		97		97
PI3K+	TC1	time		40 (28, 56)		40 (28, 56)		40 (28, 56)		40 (28, 56)		40 (28, 56)		40 (28, 56)		40 (28, 56)		40 (28, 56)
PI3K+	TC1	n		16 (9, 22)		22 (13, 33)		16 (11, 29)		11 (7, 19)		0 (0, 0)		2 (0, 5)		3 (1, 7)		0 (0, 0)
PI3K+	TC1	post_p		0.36 (0.13, 0.47)		0.34 (0.11, 0.45)		0.34 (0.11, 0.47)		0.36 (0.16, 0.48)		NA (NA, NA)		0.45 (0.34, 0.49)		0.45 (0.34, 0.48)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.028 (0.019, 0.039)		0.026 (0.019, 0.037)		0.027 (0.019, 0.038)		0.027 (0.02, 0.038)		0 (0, 0)		0.031 (0.002, 0.104)		0.033 (0.013, 0.084)		0 (0, 0.217)
PI3K+	TC2	count		93		93		93		93		93		93		93		93
PI3K+	TC2	time		40 (27, 55)		40 (27, 55)		40 (27, 55)		40 (27, 55)		40 (27, 55)		40 (27, 55)		40 (27, 55)		40 (27, 55)
PI3K+	TC2	n		14 (9, 23)		21 (15, 32)		17 (10, 27)		13 (7, 21)		0 (0, 0)		2 (0, 5)		3 (1, 7)		0 (0, 0)
PI3K+	TC2	post_p		0.34 (0.15, 0.47)		0.32 (0.1, 0.47)		0.37 (0.12, 0.48)		0.35 (0.11, 0.47)		NA (NA, NA)		0.46 (0.38, 0.49)		0.43 (0.31, 0.49)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.028 (0.019, 0.049)		0.026 (0.02, 0.034)		0.026 (0.02, 0.039)		0.027 (0.019, 0.041)		NA (NA, NA)		0.033 (0.011, 0.109)		0.032 (0.013, 0.073)		0.02 (0.004, 0.035)
PI3K+	TC3	count		13		13		13		13		13		13		13		13
PI3K+	TC3	time		37 (25, 47)		37 (25, 47)		37 (25, 47)		37 (25, 47)		37 (25, 47)		37 (25, 47)		37 (25, 47)		37 (25, 47)
PI3K+	TC3	n		14 (9, 19)		21 (10, 31)		15 (11, 21)		11 (9, 16)		0 (0, 0)		2 (0, 4)		2 (0, 5)		0 (0, 0)
PI3K+	TC3	post_p		0.36 (0.2, 0.46)		0.34 (0.2, 0.47)		0.41 (0.2, 0.47)		0.33 (0.19, 0.46)		NA (NA, NA)		0.46 (0.41, 0.5)		0.49 (0.45, 0.5)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.026 (0.019, 0.037)		0.025 (0.018, 0.032)		0.027 (0.02, 0.032)		0.029 (0.022, 0.034)		NA (NA, NA)		0.02 (0, 0.067)		0.02 (0, 0.184)		NA (NA, NA)
PI3K+	TC4	count		30		30		30		30		30		30		30		30
PI3K+	TC4	time		35 (27, 50)		35 (27, 50)		35 (27, 50)		35 (27, 50)		35 (27, 50)		35 (27, 50)		35 (27, 50)		35 (27, 50)
PI3K+	TC4	n		14 (10, 21)		20 (15, 30)		15 (10, 27)		10 (5, 21)		0 (0, 0)		2 (0, 5)		2 (0, 5)		0 (0, 0)
PI3K+	TC4	post_p		0.41 (0.22, 0.49)		0.37 (0.16, 0.46)		0.37 (0.12, 0.48)		0.41 (0.29, 0.48)		NA (NA, NA)		0.45 (0.37, 0.5)		0.46 (0.34, 0.5)		0.48 (0.48, 0.48)
PI3K+	TC4	r_prob		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.31 (0.31, 0.31)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.023 (0.016, 0.031)		0.025 (0.017, 0.034)		0.025 (0.018, 0.036)		0.027 (0.018, 0.04)		NA (NA, NA)		0.034 (0.012, 0.064)		0.03 (0.012, 0.07)		0.085 (0.07, 0.1)