Setting description

Equal randomization: TC3 more effective in the HRD+ biomarker signature (cfr scen 4)

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4
all param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.022, shape = 1.3 scale = 0.024, shape = 1.3
all summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 41.8, median = 34.2 mean = 39, median = 31.9
all effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1.07, hr = 0.91 af = 1, hr = 1
HRD+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
HRD+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
HRD+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
TP53+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.023, shape = 1.3 scale = 0.024, shape = 1.3
TP53+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39.9, median = 32.6 mean = 39, median = 31.9
TP53+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1.02, hr = 0.97 af = 1, hr = 1
TEfus+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.022, shape = 1.3 scale = 0.024, shape = 1.3
TEfus+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 42.7, median = 34.8 mean = 39, median = 31.9
TEfus+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1.09, hr = 0.89 af = 1, hr = 1
PI3K+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.023, shape = 1.3 scale = 0.024, shape = 1.3
PI3K+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 40.5, median = 33.1 mean = 39, median = 31.9
PI3K+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1.04, hr = 0.95 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4
—- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
—- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
—- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
—+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
—+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
–+- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
–+- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
–++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
–++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+– summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
-+– effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+-+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
-+-+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-++- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
-++- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
-+++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
+— summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
+— effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
+–+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
+–+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
+–+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
+-+- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
+-+- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
+-+- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
+-++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
+-++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
+-++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
++– param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
++– summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
++– effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
++-+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
++-+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
++-+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
+++- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
+++- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
+++- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
++++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
++++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
++++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4
all 3 9 75 20
HRD+ 1 2 83 8
TP53+ 4 7 41 36
TEfus+ 1 5 66 26
PI3K+ 5 6 45 21
TC1 TC2 TC3 TC4
all 0.006 0.018 0.150 0.040
HRD+ 0.002 0.004 0.166 0.016
TP53+ 0.008 0.014 0.082 0.072
TEfus+ 0.002 0.010 0.132 0.052
PI3K+ 0.010 0.012 0.090 0.042
futility (counts and proportions):
TC1 TC2 TC3 TC4
all 9 10 0 1
HRD+ 29 23 0 5
TP53+ 126 132 26 43
TEfus+ 92 93 2 18
PI3K+ 97 93 13 30
TC1 TC2 TC3 TC4
all 0.018 0.020 0.000 0.002
HRD+ 0.058 0.046 0.000 0.010
TP53+ 0.252 0.264 0.052 0.086
TEfus+ 0.184 0.186 0.004 0.036
PI3K+ 0.194 0.186 0.026 0.060
max sample size (counts and proportions):
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0


Operating characteristics

Characteristics Overall TC1 TC2 TC3 TC4
Error signature 0.478 0.028 0.05 0.304 0.194
Error subgroup 0.498 0.028 0.05 0.338 0.194
Power signature 0.166 0.000 0.00 0.166 0.000
Power subgroup 0.470 0.000 0.00 0.470 0.000

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4
all graduation 0 3 9 75 20
all futility 0 9 10 0 1
all max_n 0 0 0 0 0
all n 588 (564, 616) 305 (237, 367) 302 (238, 367) 308 (215, 356) 314 (254, 379)
all n_unique 588 (564, 616) 305 (237, 367) 302 (238, 367) 308 (215, 356) 314 (254, 379)
all time_trial 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (44, 60) 60 (60, 60)
all time_stop NA (NA, NA) 34 (11, 47) 29 (11, 52) 34 (12, 56) 26 (12, 51)
all post_p NA (NA, NA) 0.29 (0.05, 0.81) 0.36 (0.04, 0.8) 0.99 (0.83, 1) 0.87 (0.39, 1)
all rate 0.023 (0.022, 0.025) 0.025 (0.023, 0.027) 0.024 (0.022, 0.027) 0.019 (0.017, 0.021) 0.021 (0.019, 0.023)
HRD+ graduation 0 1 2 83 8
HRD+ futility 0 29 23 0 5
HRD+ max_n 0 0 0 0 0
HRD+ n 86 (73, 98) 44 (34, 55) 44 (32, 54) 44 (28, 51) 45 (35, 57)
HRD+ n_unique 86 (73, 98) 44 (34, 55) 44 (32, 54) 44 (28, 51) 45 (35, 57)
HRD+ time_trial 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (58, 60) 60 (60, 60)
HRD+ time_stop NA (NA, NA) 57 (52, 59) 56 (53, 60) 56 (47, 60) 54 (51, 57)
HRD+ post_p NA (NA, NA) 0.37 (0.08, 0.82) 0.37 (0.08, 0.82) 1 (0.97, 1) 0.6 (0.2, 0.92)
HRD+ rate 0.023 (0.02, 0.028) 0.025 (0.019, 0.031) 0.024 (0.018, 0.031) 0.009 (0.006, 0.013) 0.021 (0.016, 0.027)
TP53+ graduation 0 4 7 41 36
TP53+ futility 0 126 132 26 43
TP53+ max_n 0 0 0 0 0
TP53+ n 219 (201, 237) 114 (56, 147) 112 (57, 151) 116 (59, 151) 119 (75, 158)
TP53+ n_unique 219 (201, 237) 114 (56, 147) 112 (57, 151) 116 (59, 151) 119 (75, 158)
TP53+ time_trial 60 (60, 60) 60 (31, 60) 60 (31, 60) 60 (49, 60) 60 (42, 60)
TP53+ time_stop NA (NA, NA) 34 (24, 50) 38 (25, 53) 38 (28, 56) 39 (27, 55)
TP53+ post_p NA (NA, NA) 0.36 (0.07, 0.82) 0.38 (0.06, 0.82) 0.81 (0.38, 0.98) 0.76 (0.28, 0.98)
TP53+ rate 0.023 (0.021, 0.026) 0.025 (0.021, 0.03) 0.025 (0.021, 0.029) 0.02 (0.017, 0.024) 0.021 (0.017, 0.025)
TEfus+ graduation 0 1 5 66 26
TEfus+ futility 0 92 93 2 18
TEfus+ max_n 0 0 0 0 0
TEfus+ n 193 (174, 208) 100 (60, 130) 98 (58, 127) 100 (56, 127) 104 (69, 136)
TEfus+ n_unique 193 (174, 208) 100 (60, 130) 98 (58, 127) 100 (56, 127) 104 (69, 136)
TEfus+ time_trial 60 (60, 60) 60 (41, 60) 60 (39, 60) 60 (49, 60) 60 (60, 60)
TEfus+ time_stop NA (NA, NA) 41 (30, 55) 39 (30, 53) 41 (31, 57) 40 (29, 54)
TEfus+ post_p NA (NA, NA) 0.39 (0.05, 0.84) 0.41 (0.06, 0.82) 0.92 (0.57, 1) 0.74 (0.33, 0.98)
TEfus+ rate 0.024 (0.021, 0.026) 0.025 (0.021, 0.03) 0.025 (0.021, 0.03) 0.018 (0.015, 0.022) 0.021 (0.017, 0.025)
PI3K+ graduation 0 5 6 45 21
PI3K+ futility 0 97 93 13 30
PI3K+ max_n 0 0 0 0 0
PI3K+ n 206 (188, 226) 107 (67, 138) 106 (64, 140) 108 (57, 139) 115 (76, 148)
PI3K+ n_unique 206 (188, 226) 107 (67, 138) 106 (64, 140) 108 (57, 139) 115 (76, 148)
PI3K+ time_trial 60 (60, 60) 60 (40, 60) 60 (41, 60) 60 (57, 60) 60 (60, 60)
PI3K+ time_stop NA (NA, NA) 40 (28, 56) 41 (27, 55) 42 (28, 58) 38 (29, 52)
PI3K+ post_p NA (NA, NA) 0.39 (0.06, 0.81) 0.38 (0.07, 0.81) 0.83 (0.39, 0.99) 0.76 (0.25, 0.98)
PI3K+ rate 0.024 (0.021, 0.026) 0.025 (0.021, 0.03) 0.025 (0.021, 0.029) 0.02 (0.017, 0.024) 0.021 (0.017, 0.026)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4
—- graduation 0 3 9 75 20
—- futility 0 9 10 0 1
—- max_n 0 0 0 0 0
—- n 176 (161, 194) 92 (78, 109) 93 (79, 107) 91 (65, 106) 91 (77, 107)
—- n_unique 176 (161, 194) 92 (78, 109) 93 (79, 107) 91 (65, 106) 91 (77, 107)
—- post_p NA (NA, NA) 0.41 (0.07, 0.83) 0.38 (0.07, 0.83) 0.74 (0.27, 0.97) 0.74 (0.29, 0.96)
—- rate 0.023 (0.021, 0.026) 0.025 (0.02, 0.029) 0.025 (0.02, 0.029) 0.021 (0.017, 0.025) 0.021 (0.017, 0.025)
—+ graduation 0 8 13 109 40
—+ futility 0 99 95 13 30
—+ max_n 0 0 0 0 0
—+ n 42 (33, 51) 22 (13, 30) 22 (13, 29) 22 (12, 29) 23 (14, 31)
—+ n_unique 42 (33, 51) 22 (13, 30) 22 (13, 29) 22 (12, 29) 23 (14, 31)
—+ post_p NA (NA, NA) 0.46 (0.1, 0.81) 0.47 (0.12, 0.87) 0.59 (0.2, 0.91) 0.62 (0.23, 0.92)
—+ rate 0.023 (0.017, 0.03) 0.025 (0.017, 0.037) 0.024 (0.016, 0.035) 0.022 (0.014, 0.032) 0.021 (0.014, 0.03)
–+- graduation 0 4 14 129 46
–+- futility 0 95 97 2 19
–+- max_n 0 0 0 0 0
–+- n 13 (9, 19) 7 (3, 11) 7 (3, 11) 6 (2, 11) 7 (3, 11)
–+- n_unique 13 (9, 19) 7 (3, 11) 7 (3, 11) 6 (2, 11) 7 (3, 11)
–+- post_p NA (NA, NA) 0.47 (0.18, 0.75) 0.48 (0.21, 0.76) 0.56 (0.28, 0.79) 0.53 (0.27, 0.82)
–+- rate 0.024 (0.014, 0.037) 0.025 (0.011, 0.05) 0.024 (0.012, 0.047) 0.02 (0.008, 0.041) 0.021 (0.008, 0.042)
–++ graduation 0 8 18 149 63
–++ futility 0 153 154 15 43
–++ max_n 0 0 0 0 0
–++ n 62 (52, 72) 31 (18, 45) 31 (18, 44) 31 (16, 43) 33 (20, 47)
–++ n_unique 62 (52, 72) 31 (18, 45) 31 (18, 44) 31 (16, 43) 33 (20, 47)
–++ post_p NA (NA, NA) 0.44 (0.1, 0.81) 0.43 (0.09, 0.82) 0.64 (0.24, 0.93) 0.62 (0.22, 0.93)
–++ rate 0.023 (0.019, 0.029) 0.025 (0.019, 0.034) 0.025 (0.018, 0.035) 0.021 (0.015, 0.028) 0.021 (0.015, 0.029)
-+– graduation 0 7 15 104 55
-+– futility 0 129 133 26 43
-+– max_n 0 0 0 0 0
-+– n 76 (66, 87) 39 (21, 54) 39 (21, 53) 40 (21, 54) 41 (25, 54)
-+– n_unique 76 (66, 87) 39 (21, 54) 39 (21, 53) 40 (21, 54) 41 (25, 54)
-+– post_p NA (NA, NA) 0.41 (0.07, 0.84) 0.45 (0.11, 0.83) 0.66 (0.22, 0.92) 0.64 (0.2, 0.95)
-+– rate 0.023 (0.019, 0.028) 0.025 (0.018, 0.033) 0.024 (0.019, 0.032) 0.021 (0.016, 0.028) 0.021 (0.015, 0.029)
-+-+ graduation 0 12 18 132 69
-+-+ futility 0 172 173 36 68
-+-+ max_n 0 0 0 0 0
-+-+ n 51 (41, 61) 26 (12, 36) 26 (13, 37) 27 (12, 38) 28 (14, 41)
-+-+ n_unique 51 (41, 61) 26 (12, 36) 26 (13, 37) 27 (12, 38) 28 (14, 41)
-+-+ post_p NA (NA, NA) 0.44 (0.1, 0.83) 0.42 (0.11, 0.81) 0.58 (0.21, 0.91) 0.6 (0.21, 0.92)
-+-+ rate 0.023 (0.018, 0.029) 0.025 (0.017, 0.034) 0.025 (0.017, 0.034) 0.022 (0.014, 0.03) 0.021 (0.014, 0.03)
-++- graduation 0 8 19 150 78
-++- futility 0 180 183 28 57
-++- max_n 0 0 0 0 0
-++- n 45 (38, 54) 23 (11, 34) 23 (11, 34) 23 (12, 35) 25 (13, 37)
-++- n_unique 45 (38, 54) 23 (11, 34) 23 (11, 34) 23 (12, 35) 25 (13, 37)
-++- post_p NA (NA, NA) 0.45 (0.11, 0.83) 0.45 (0.11, 0.82) 0.63 (0.25, 0.91) 0.62 (0.22, 0.92)
-++- rate 0.024 (0.018, 0.03) 0.024 (0.017, 0.036) 0.025 (0.016, 0.037) 0.021 (0.013, 0.03) 0.021 (0.014, 0.03)
-+++ graduation 0 12 22 169 91
-+++ futility 0 210 213 38 79
-+++ max_n 0 0 0 0 0
-+++ n 36 (29, 43) 17 (8, 28) 17 (8, 28) 19 (8, 29) 20 (10, 31)
-+++ n_unique 36 (29, 43) 17 (8, 28) 17 (8, 28) 19 (8, 29) 20 (10, 31)
-+++ post_p NA (NA, NA) 0.43 (0.12, 0.81) 0.45 (0.13, 0.81) 0.62 (0.25, 0.9) 0.63 (0.25, 0.91)
-+++ rate 0.024 (0.018, 0.031) 0.026 (0.017, 0.038) 0.025 (0.017, 0.037) 0.021 (0.013, 0.032) 0.021 (0.013, 0.031)
+— graduation 0 4 11 154 27
+— futility 0 38 33 0 6
+— max_n 0 0 0 0 0
+— n 40 (32, 49) 21 (15, 28) 21 (14, 27) 20 (12, 27) 21 (15, 28)
+— n_unique 40 (32, 49) 21 (15, 28) 21 (14, 27) 20 (12, 27) 21 (15, 28)
+— post_p NA (NA, NA) 0.42 (0.1, 0.8) 0.4 (0.1, 0.78) 0.96 (0.78, 1) 0.53 (0.17, 0.87)
+— rate 0.023 (0.017, 0.03) 0.024 (0.016, 0.034) 0.024 (0.016, 0.035) 0.009 (0.004, 0.015) 0.022 (0.014, 0.031)
+–+ graduation 0 9 15 181 47
+–+ futility 0 119 111 13 34
+–+ max_n 0 0 0 0 0
+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.51)
+–+ rate 0.038 (0.007, 0.053) 0 (0, 0.041) 0 (0, 0) 0 (0, 0) 0 (0, 0.16)
+-+- graduation 0 5 16 204 53
+-+- futility 0 120 117 2 24
+-+- max_n 0 0 0 0 0
+-+- n 28 (21, 36) 15 (8, 21) 14 (8, 21) 14 (7, 20) 15 (9, 21)
+-+- n_unique 28 (21, 36) 15 (8, 21) 14 (8, 21) 14 (7, 20) 15 (9, 21)
+-+- post_p NA (NA, NA) 0.42 (0.1, 0.78) 0.41 (0.13, 0.77) 0.93 (0.67, 0.99) 0.54 (0.19, 0.87)
+-+- rate 0.024 (0.016, 0.033) 0.024 (0.016, 0.038) 0.025 (0.014, 0.038) 0.008 (0.003, 0.016) 0.021 (0.012, 0.032)
+-++ graduation 0 9 20 218 70
+-++ futility 0 172 168 15 47
+-++ max_n 0 0 0 0 0
+-++ n 7 (3, 11) 3 (1, 7) 3 (1, 6) 3 (1, 6) 4 (1, 7)
+-++ n_unique 7 (3, 11) 3 (1, 7) 3 (1, 6) 3 (1, 6) 4 (1, 7)
+-++ post_p NA (NA, NA) 0.47 (0.3, 0.65) 0.48 (0.3, 0.64) 0.59 (0.43, 0.82) 0.5 (0.33, 0.67)
+-++ rate 0.024 (0.008, 0.045) 0.024 (0, 0.064) 0.024 (0, 0.063) 0.008 (0, 0.034) 0.022 (0, 0.052)
++– graduation 0 8 17 178 59
++– futility 0 151 148 25 48
++– max_n 0 0 0 0 0
++– n 1 (0, 3) 0 (0, 2) 0 (0, 2) 0 (0, 2) 1 (0, 2)
++– n_unique 1 (0, 3) 0 (0, 2) 0 (0, 2) 0 (0, 2) 1 (0, 2)
++– post_p NA (NA, NA) 0.48 (0.42, 0.56) 0.48 (0.42, 0.56) 0.53 (0.46, 0.58) 0.5 (0.43, 0.56)
++– rate 0.019 (0, 0.071) 0.024 (0, 0.106) 0.024 (0, 0.122) 0 (0, 0.039) 0.014 (0, 0.094)
++-+ graduation 0 13 20 201 73
++-+ futility 0 188 184 35 72
++-+ max_n 0 0 0 0 0
++-+ n 9 (5, 13) 4 (1, 8) 4 (1, 8) 4 (1, 8) 5 (2, 9)
++-+ n_unique 9 (5, 13) 4 (1, 8) 4 (1, 8) 4 (1, 8) 5 (2, 9)
++-+ post_p NA (NA, NA) 0.46 (0.27, 0.68) 0.46 (0.22, 0.71) 0.65 (0.47, 0.86) 0.5 (0.29, 0.71)
++-+ rate 0.023 (0.011, 0.04) 0.024 (0.008, 0.054) 0.025 (0.006, 0.055) 0.009 (0, 0.025) 0.021 (0.006, 0.056)
+++- graduation 0 9 21 221 82
+++- futility 0 199 195 27 62
+++- max_n 0 0 0 0 0
+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
+++- rate 0.064 (0, 0.278) 0.055 (0.051, 0.059) 0.018 (0, 0.051) 0.021 (0.021, 0.021) 0 (0, 0)
++++ graduation 0 13 24 235 95
++++ futility 0 225 222 37 83
++++ max_n 0 0 0 0 0
++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ post_p NA (NA, NA) 0.48 (0.48, 0.48) NA (NA, NA) 0.51 (0.51, 0.51) 0.48 (0.46, 0.5)
++++ rate 0 (0, 0.069) 0.044 (0, 0.261) 0.012 (0, 0.034) 0 (0, 0.039) 0 (0, 0.111)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4
all count 3 9 75 20
all time_stop 11 (10, 11) 23 (11, 52) 34 (12, 56) 26 (12, 52)
all n_trt 54 (52, 58) 129 (55, 262) 174 (65, 300) 130 (59, 300)
all n_control 104 (88, 123) 201 (92, 551) 336 (106, 545) 261 (114, 517)
all post_p 0.96 (0.94, 0.97) 0.96 (0.91, 1) 0.99 (0.92, 1) 0.98 (0.89, 1)
all order 1 (1, 1) 1 (1, 2.4) 1 (1, 2) 1 (1, 2.1)
HRD+ count 1 2 83 8
HRD+ time_stop 54 (54, 54) 59 (59, 59) 56 (47, 60) 52 (50, 57)
HRD+ n_trt 50 (50, 50) 50 (50, 50) 50 (50, 52) 52 (50, 54)
HRD+ n_control 83 (83, 83) 84 (83, 85) 79 (63, 95) 80 (69, 89)
HRD+ post_p 1 (1, 1) 0.97 (0.97, 0.98) 1 (0.98, 1) 0.98 (0.95, 0.99)
HRD+ order 7 (7, 7) 1.5 (1.1, 1.9) 1 (1, 2) 2 (1, 2.3)
TP53+ count 4 7 41 36
TP53+ time_stop 37 (28, 48) 49 (30, 53) 42 (30, 57) 42 (30, 57)
TP53+ n_trt 74 (54, 113) 76 (57, 108) 81 (52, 118) 86 (52, 122)
TP53+ n_control 132 (102, 186) 177 (110, 201) 151 (111, 201) 151 (104, 217)
TP53+ post_p 0.96 (0.93, 0.99) 0.96 (0.94, 0.99) 0.98 (0.94, 1) 0.98 (0.92, 1)
TP53+ order 1 (1, 1) 1 (1, 3.2) 1 (1, 3) 1 (1, 2)
TEfus+ count 1 5 66 26
TEfus+ time_stop 37 (37, 37) 39 (34, 48) 41 (30, 57) 42 (34, 55)
TEfus+ n_trt 51 (51, 51) 64 (56, 93) 68 (52, 95) 71 (52, 102)
TEfus+ n_control 119 (119, 119) 116 (98, 158) 130 (94, 174) 138 (98, 182)
TEfus+ post_p 0.97 (0.97, 0.97) 0.99 (0.96, 0.99) 0.99 (0.95, 1) 0.99 (0.94, 1)
TEfus+ order 1 (1, 1) 1 (1, 1) 1 (1, 3) 1 (1, 3)
PI3K+ count 5 6 45 21
PI3K+ time_stop 35 (28, 54) 46 (32, 56) 42 (30, 58) 40 (30, 55)
PI3K+ n_trt 54 (52, 96) 92 (58, 104) 69 (51, 110) 76 (51, 124)
PI3K+ n_control 121 (108, 178) 157 (103, 211) 144 (103, 202) 148 (88, 198)
PI3K+ post_p 0.97 (0.93, 1) 0.99 (0.97, 1) 0.99 (0.96, 1) 0.98 (0.95, 1)
PI3K+ order 1 (1, 1.6) 2.5 (1.5, 3.5) 2 (1, 3) 1 (1, 2)
Futility:
signature var TC1 TC2 TC3 TC4
all count 9 10 1
all time_stop 39 (23, 47) 30 (24, 50) 40 (40, 40)
all n_trt 193 (116, 218) 168 (138, 228) 172 (172, 172)
all n_control 389 (221, 491) 296 (233, 506) 398 (398, 398)
all post_p 0.04 (0.01, 0.06) 0.02 (0, 0.07) 0.02 (0.02, 0.02)
all order 2 (1, 3.4) 1.5 (1, 3.2) 3 (3, 3)
HRD+ count 29 23 5
HRD+ time_stop 57 (52, 59) 55 (53, 60) 54 (53, 58)
HRD+ n_trt 52 (50, 64) 51 (50, 52) 52 (50, 62)
HRD+ n_control 79 (67, 94) 79 (71, 90) 93 (72, 94)
HRD+ post_p 0.1 (0.01, 0.21) 0.1 (0.02, 0.26) 0.14 (0.07, 0.24)
HRD+ order 2 (1, 4) 3 (1, 4.8) 3 (3, 4)
TP53+ count 126 132 26 43
TP53+ time_stop 34 (24, 50) 38 (25, 53) 37 (26, 48) 36 (26, 52)
TP53+ n_trt 64 (51, 100) 68 (50, 113) 65 (52, 105) 69 (51, 112)
TP53+ n_control 122 (84, 181) 132 (84, 193) 130 (94, 182) 127 (92, 192)
TP53+ post_p 0.1 (0.02, 0.24) 0.09 (0.02, 0.24) 0.15 (0.04, 0.24) 0.13 (0.02, 0.26)
TP53+ order 1 (1, 2.5) 2 (1, 3) 1 (1, 3) 1 (1, 3)
TEfus+ count 92 93 2 18
TEfus+ time_stop 41 (30, 55) 39 (30, 54) 41 (35, 47) 37 (26, 47)
TEfus+ n_trt 64 (50, 93) 62 (51, 94) 66 (56, 75) 55 (50, 86)
TEfus+ n_control 124 (92, 168) 125 (91, 176) 137 (123, 151) 110 (75, 155)
TEfus+ post_p 0.08 (0.02, 0.22) 0.08 (0.01, 0.23) 0.2 (0.16, 0.23) 0.13 (0.02, 0.17)
TEfus+ order 2 (1, 3) 2 (1, 3.8) 1 (1, 1) 1 (1, 2)
PI3K+ count 97 93 13 30
PI3K+ time_stop 40 (28, 56) 40 (27, 55) 37 (25, 47) 35 (27, 50)
PI3K+ n_trt 73 (52, 108) 71 (51, 104) 61 (51, 86) 64 (52, 113)
PI3K+ n_control 140 (89, 190) 136 (87, 192) 109 (80, 179) 122 (90, 162)
PI3K+ post_p 0.09 (0.02, 0.24) 0.09 (0.02, 0.23) 0.08 (0.04, 0.21) 0.12 (0.02, 0.28)
PI3K+ order 2 (1, 4) 2 (1, 4) 1 (1, 3) 1 (1, 4)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
all TC1 time 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11) 11 (10, 11)
all TC1 n 15 (13, 17) 3 (2, 5) 1 (0, 2) 6 (5, 7) 6 (4, 9) 6 (5, 7) 4 (3, 5) 3 (2, 6) 5 (3, 5) 0 (0, 0) 3 (1, 3) 1 (0, 2) 0 (0, 0) 1 (0, 1) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.62 (0.61, 0.62) 0.52 (0.51, 0.58) 0.52 (0.52, 0.52) 0.52 (0.51, 0.54) 0.55 (0.54, 0.67) 0.58 (0.54, 0.58) 0.56 (0.54, 0.57) 0.52 (0.5, 0.54) 0.5 (0.5, 0.54) NA (NA, NA) 0.53 (0.52, 0.53) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.014 (0.003, 0.015) 0 (0, 0.051) 0 (0, 0) 0 (0, 0) 0 (0, 0.03) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.361 (0.072, 0.65) NA (NA, NA) NA (NA, NA)
all TC2 count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
all TC2 time 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52) 23 (11, 52)
all TC2 n 35 (16, 77) 11 (2, 21) 2 (0, 5) 13 (4, 28) 13 (6, 37) 10 (4, 17) 5 (2, 19) 6 (3, 18) 7 (4, 17) 0 (0, 0) 5 (1, 14) 2 (0, 3) 0 (0, 0) 1 (0, 3) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.7 (0.55, 0.93) 0.64 (0.51, 0.78) 0.56 (0.51, 0.63) 0.64 (0.57, 0.82) 0.57 (0.53, 0.67) 0.55 (0.51, 0.63) 0.53 (0.52, 0.61) 0.57 (0.52, 0.88) 0.57 (0.51, 0.66) NA (NA, NA) 0.53 (0.51, 0.66) 0.52 (0.5, 0.56) NA (NA, NA) 0.54 (0.53, 0.65) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.01 (0, 0.021) 0.006 (0, 0.024) 0 (0, 0.03) 0.01 (0, 0.018) 0.012 (0, 0.021) 0.007 (0, 0.02) 0.007 (0, 0.019) 0 (0, 0.016) 0 (0, 0.016) NA (NA, NA) 0 (0, 0.018) 0.009 (0, 0.052) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
all TC3 count 75 75 75 75 75 75 75 75 75 75 75 75 75 75 75 75
all TC3 time 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56) 34 (12, 56)
all TC3 n 53 (18, 92) 13 (4, 23) 4 (0, 8) 17 (6, 31) 22 (10, 37) 16 (4, 28) 13 (6, 26) 9 (4, 19) 11 (4, 19) 0 (0, 0) 7 (2, 16) 2 (0, 5) 0 (0, 1) 2 (0, 6) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.69 (0.54, 0.95) 0.6 (0.53, 0.82) 0.56 (0.51, 0.8) 0.61 (0.52, 0.89) 0.6 (0.52, 0.91) 0.62 (0.51, 0.89) 0.59 (0.51, 0.84) 0.57 (0.51, 0.83) 0.66 (0.54, 0.96) NA (NA, NA) 0.7 (0.53, 0.95) 0.55 (0.51, 0.65) 0.53 (0.52, 0.61) 0.55 (0.51, 0.72) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.016 (0.007, 0.022) 0.013 (0, 0.024) 0.007 (0, 0.019) 0.014 (0, 0.021) 0.015 (0, 0.023) 0.016 (0, 0.022) 0.015 (0, 0.023) 0.012 (0, 0.023) 0.007 (0, 0.016) NA (NA, NA) 0.002 (0, 0.013) 0 (0, 0.022) 0 (0, 0.025) 0 (0, 0.02) 0 (0, 0) 0.011 (0, 0.378)
all TC4 count 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20
all TC4 time 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52) 26 (12, 52)
all TC4 n 40 (17, 96) 8 (1, 17) 3 (1, 8) 12 (4, 31) 22 (9, 39) 14 (4, 26) 10 (4, 25) 10 (2, 22) 9 (4, 21) 0 (0, 0) 7 (2, 17) 1 (0, 4) 0 (0, 1) 3 (0, 6) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.72 (0.53, 0.9) 0.61 (0.52, 0.77) 0.55 (0.51, 0.6) 0.58 (0.52, 0.78) 0.59 (0.51, 0.91) 0.61 (0.53, 0.73) 0.55 (0.51, 0.74) 0.63 (0.52, 0.8) 0.55 (0.51, 0.77) NA (NA, NA) 0.56 (0.51, 0.82) 0.56 (0.52, 0.59) 0.52 (0.51, 0.54) 0.55 (0.51, 0.62) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.016 (0.008, 0.022) 0.006 (0, 0.02) 0 (0, 0.02) 0.012 (0, 0.023) 0.014 (0, 0.023) 0.013 (0, 0.021) 0.014 (0, 0.02) 0.009 (0, 0.021) 0.011 (0, 0.021) NA (NA, NA) 0.008 (0, 0.018) 0.01 (0, 0.026) 0 (0, 0.008) 0 (0, 0.017) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 1 1 1 1 1 1 1 1
HRD+ TC1 time 54 (54, 54) 54 (54, 54) 54 (54, 54) 54 (54, 54) 54 (54, 54) 54 (54, 54) 54 (54, 54) 54 (54, 54)
HRD+ TC1 n 25 (25, 25) 0 (0, 0) 17 (17, 17) 5 (5, 5) 1 (1, 1) 2 (2, 2) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.92 (0.92, 0.92) NA (NA, NA) 0.7 (0.7, 0.7) 0.95 (0.95, 0.95) 0.55 (0.55, 0.55) 0.58 (0.58, 0.58) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.013 (0.013, 0.013) NA (NA, NA) 0.021 (0.021, 0.021) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 2 2 2 2 2 2 2 2
HRD+ TC2 time 59 (59, 59) 59 (59, 59) 59 (59, 59) 59 (59, 59) 59 (59, 59) 59 (59, 59) 59 (59, 59) 59 (59, 59)
HRD+ TC2 n 25 (24, 26) 0 (0, 0) 16 (15, 17) 7 (6, 8) 0 (0, 1) 2 (0, 3) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.82 (0.8, 0.83) NA (NA, NA) 0.84 (0.82, 0.86) 0.67 (0.55, 0.78) 0.52 (0.52, 0.52) 0.77 (0.77, 0.77) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.016 (0.015, 0.018) NA (NA, NA) 0.012 (0.01, 0.013) 0.03 (0.025, 0.035) 0 (0, 0) 0.008 (0.008, 0.008) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 83 83 83 83 83 83 83 83
HRD+ TC3 time 56 (47, 60) 56 (47, 60) 56 (47, 60) 56 (47, 60) 56 (47, 60) 56 (47, 60) 56 (47, 60) 56 (47, 60)
HRD+ TC3 n 23 (18, 29) 0 (0, 0) 17 (11, 22) 4 (2, 7) 1 (0, 2) 5 (3, 9) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.97 (0.77, 1) NA (NA, NA) 0.94 (0.79, 0.99) 0.62 (0.53, 0.81) 0.53 (0.5, 0.58) 0.65 (0.52, 0.87) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.008 (0.004, 0.014) NA (NA, NA) 0.007 (0.003, 0.014) 0.006 (0, 0.015) 0 (0, 0.019) 0.008 (0, 0.018) NA (NA, NA) 0.265 (0.053, 0.477)
HRD+ TC4 count 8 8 8 8 8 8 8 8
HRD+ TC4 time 52 (50, 57) 52 (50, 57) 52 (50, 57) 52 (50, 57) 52 (50, 57) 52 (50, 57) 52 (50, 57) 52 (50, 57)
HRD+ TC4 n 22 (17, 27) 0 (0, 0) 19 (15, 21) 4 (3, 9) 0 (0, 1) 6 (3, 10) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.81 (0.7, 0.9) NA (NA, NA) 0.84 (0.75, 0.94) 0.59 (0.51, 0.62) NA (NA, NA) 0.68 (0.52, 0.8) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.016 (0.013, 0.021) NA (NA, NA) 0.013 (0.011, 0.015) 0.015 (0, 0.027) 0 (0, 0) 0.012 (0.005, 0.024) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 4 4 4 4 4 4 4 4
TP53+ TC1 time 37 (28, 48) 37 (28, 48) 37 (28, 48) 37 (28, 48) 37 (28, 48) 37 (28, 48) 37 (28, 48) 37 (28, 48)
TP53+ TC1 n 28 (21, 43) 18 (11, 28) 15 (11, 21) 12 (8, 17) 0 (0, 1) 2 (0, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.71 (0.7, 0.89) 0.83 (0.65, 0.87) 0.72 (0.59, 0.76) 0.81 (0.8, 0.9) 0.5 (0.5, 0.5) 0.52 (0.52, 0.56) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.012 (0.009, 0.014) 0.013 (0.009, 0.016) 0.013 (0.007, 0.014) 0.012 (0.003, 0.013) 0 (0, 0) 0.016 (0.003, 0.024) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 7 7 7 7 7 7 7 7
TP53+ TC2 time 49 (30, 53) 49 (30, 53) 49 (30, 53) 49 (30, 53) 49 (30, 53) 49 (30, 53) 49 (30, 53) 49 (30, 53)
TP53+ TC2 n 30 (22, 36) 15 (9, 26) 19 (8, 25) 16 (7, 21) 0 (0, 1) 2 (0, 9) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.73 (0.71, 0.76) 0.78 (0.66, 0.93) 0.77 (0.6, 0.85) 0.73 (0.52, 0.76) 0.57 (0.56, 0.58) 0.54 (0.54, 0.56) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.019 (0.015, 0.024) 0.018 (0.008, 0.021) 0.014 (0.011, 0.025) 0.021 (0.01, 0.025) 0 (0, 0) 0 (0, 0.016) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 41 41 41 41 41 41 41 41
TP53+ TC3 time 42 (30, 57) 42 (30, 57) 42 (30, 57) 42 (30, 57) 42 (30, 57) 42 (30, 57) 42 (30, 57) 42 (30, 57)
TP53+ TC3 n 27 (18, 43) 18 (10, 28) 16 (11, 24) 13 (6, 24) 0 (0, 2) 4 (1, 7) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.8 (0.72, 0.94) 0.73 (0.66, 0.84) 0.78 (0.7, 0.88) 0.74 (0.53, 0.92) 0.54 (0.5, 0.63) 0.58 (0.53, 0.72) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.015 (0.009, 0.021) 0.016 (0.008, 0.019) 0.013 (0.005, 0.021) 0.013 (0.007, 0.022) 0 (0, 0) 0 (0, 0.013) 0 (0, 0) NA (NA, NA)
TP53+ TC4 count 36 36 36 36 36 36 36 36
TP53+ TC4 time 42 (30, 57) 42 (30, 57) 42 (30, 57) 42 (30, 57) 42 (30, 57) 42 (30, 57) 42 (30, 57) 42 (30, 57)
TP53+ TC4 n 29 (22, 46) 20 (10, 29) 17 (9, 24) 16 (7, 22) 0 (0, 2) 4 (2, 8) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.81 (0.71, 0.96) 0.77 (0.71, 0.94) 0.78 (0.59, 0.92) 0.75 (0.55, 0.93) 0.54 (0.51, 0.6) 0.55 (0.51, 0.67) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.016 (0.01, 0.019) 0.014 (0.006, 0.019) 0.016 (0.009, 0.021) 0.014 (0.004, 0.019) 0 (0, 0.03) 0.013 (0, 0.029) NA (NA, NA) 0.113 (0.113, 0.113)
TEfus+ TC1 count 1 1 1 1 1 1 1 1
TEfus+ TC1 time 37 (37, 37) 37 (37, 37) 37 (37, 37) 37 (37, 37) 37 (37, 37) 37 (37, 37) 37 (37, 37) 37 (37, 37)
TEfus+ TC1 n 6 (6, 6) 16 (16, 16) 15 (15, 15) 10 (10, 10) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.56 (0.56, 0.56) 0.73 (0.73, 0.73) 0.82 (0.82, 0.82) 0.87 (0.87, 0.87) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.019 (0.019, 0.019) 0.016 (0.016, 0.016) 0.011 (0.011, 0.011) 0 (0, 0) 0.014 (0.014, 0.014) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 5 5 5 5 5 5 5 5
TEfus+ TC2 time 39 (34, 48) 39 (34, 48) 39 (34, 48) 39 (34, 48) 39 (34, 48) 39 (34, 48) 39 (34, 48) 39 (34, 48)
TEfus+ TC2 n 5 (4, 7) 18 (16, 34) 19 (12, 24) 12 (9, 18) 9 (7, 10) 6 (1, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.55 (0.52, 0.64) 0.89 (0.74, 0.91) 0.77 (0.6, 0.81) 0.7 (0.61, 0.88) 0.58 (0.53, 0.73) 0.54 (0.52, 0.56) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.009 (0.007, 0.016) 0.013 (0.008, 0.02) 0.017 (0.009, 0.019) 0.01 (0.009, 0.022) 0.014 (0.004, 0.02) 0.014 (0.004, 0.019) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 66 66 66 66 66 66 66 66
TEfus+ TC3 time 41 (30, 57) 41 (30, 57) 41 (30, 57) 41 (30, 57) 41 (30, 57) 41 (30, 57) 41 (30, 57) 41 (30, 57)
TEfus+ TC3 n 4 (2, 9) 22 (14, 32) 16 (11, 25) 13 (8, 20) 10 (6, 17) 2 (0, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.58 (0.51, 0.77) 0.76 (0.71, 0.94) 0.78 (0.7, 0.89) 0.76 (0.59, 0.89) 0.81 (0.57, 0.97) 0.55 (0.52, 0.71) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.012 (0, 0.023) 0.014 (0.008, 0.02) 0.016 (0.005, 0.019) 0.012 (0.006, 0.022) 0.007 (0, 0.015) 0 (0, 0.021) NA (NA, NA) 0 (0, 0)
TEfus+ TC4 count 26 26 26 26 26 26 26 26
TEfus+ TC4 time 42 (34, 55) 42 (34, 55) 42 (34, 55) 42 (34, 55) 42 (34, 55) 42 (34, 55) 42 (34, 55) 42 (34, 55)
TEfus+ TC4 n 6 (1, 8) 23 (16, 34) 18 (10, 28) 14 (8, 22) 9 (6, 14) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.59 (0.51, 0.79) 0.82 (0.72, 0.96) 0.77 (0.65, 0.96) 0.76 (0.6, 0.88) 0.65 (0.52, 0.9) 0.54 (0.51, 0.62) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.014 (0, 0.023) 0.014 (0.009, 0.021) 0.014 (0.007, 0.019) 0.013 (0.007, 0.019) 0.012 (0.005, 0.02) 0 (0, 0.022) NA (NA, NA) 0 (0, 0)
PI3K+ TC1 count 5 5 5 5 5 5 5 5
PI3K+ TC1 time 35 (28, 54) 35 (28, 54) 35 (28, 54) 35 (28, 54) 35 (28, 54) 35 (28, 54) 35 (28, 54) 35 (28, 54)
PI3K+ TC1 n 13 (7, 17) 21 (15, 26) 19 (10, 28) 10 (8, 20) 0 (0, 0) 1 (0, 4) 3 (1, 4) 0 (0, 0)
PI3K+ TC1 post_p 0.74 (0.64, 0.84) 0.82 (0.75, 0.91) 0.77 (0.61, 0.84) 0.61 (0.54, 0.9) NA (NA, NA) 0.53 (0.53, 0.57) 0.59 (0.54, 0.62) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.01 (0.003, 0.018) 0.017 (0.004, 0.021) 0.014 (0.01, 0.02) 0.017 (0.005, 0.027) NA (NA, NA) 0 (0, 0.009) 0.007 (0, 0.02) NA (NA, NA)
PI3K+ TC2 count 6 6 6 6 6 6 6 6
PI3K+ TC2 time 46 (32, 56) 46 (32, 56) 46 (32, 56) 46 (32, 56) 46 (32, 56) 46 (32, 56) 46 (32, 56) 46 (32, 56)
PI3K+ TC2 n 20 (14, 28) 29 (16, 38) 14 (12, 24) 16 (12, 19) 0 (0, 0) 2 (1, 3) 2 (0, 4) 0 (0, 0)
PI3K+ TC2 post_p 0.75 (0.65, 0.83) 0.82 (0.75, 0.9) 0.84 (0.7, 0.93) 0.78 (0.74, 0.91) NA (NA, NA) 0.51 (0.5, 0.52) 0.56 (0.53, 0.58) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.016 (0.01, 0.022) 0.016 (0.01, 0.02) 0.013 (0.012, 0.021) 0.018 (0.014, 0.027) NA (NA, NA) 0.008 (0, 0.023) 0.003 (0, 0.027) NA (NA, NA)
PI3K+ TC3 count 45 45 45 45 45 45 45 45
PI3K+ TC3 time 42 (30, 58) 42 (30, 58) 42 (30, 58) 42 (30, 58) 42 (30, 58) 42 (30, 58) 42 (30, 58) 42 (30, 58)
PI3K+ TC3 n 16 (10, 26) 21 (14, 35) 18 (10, 31) 12 (8, 22) 0 (0, 0) 2 (0, 5) 3 (1, 7) 0 (0, 0)
PI3K+ TC3 post_p 0.74 (0.69, 0.91) 0.79 (0.71, 0.9) 0.76 (0.62, 0.94) 0.74 (0.58, 0.91) NA (NA, NA) 0.56 (0.52, 0.66) 0.57 (0.53, 0.73) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.014 (0.006, 0.02) 0.015 (0.008, 0.019) 0.015 (0.008, 0.022) 0.013 (0.006, 0.02) NA (NA, NA) 0 (0, 0.024) 0 (0, 0.017) 0 (0, 0)
PI3K+ TC4 count 21 21 21 21 21 21 21 21
PI3K+ TC4 time 40 (30, 55) 40 (30, 55) 40 (30, 55) 40 (30, 55) 40 (30, 55) 40 (30, 55) 40 (30, 55) 40 (30, 55)
PI3K+ TC4 n 15 (9, 24) 21 (16, 37) 22 (10, 35) 16 (5, 23) 0 (0, 0) 2 (1, 6) 4 (2, 7) 0 (0, 0)
PI3K+ TC4 post_p 0.75 (0.58, 0.94) 0.77 (0.72, 0.94) 0.78 (0.72, 0.91) 0.76 (0.62, 0.9) NA (NA, NA) 0.55 (0.51, 0.6) 0.54 (0.51, 0.64) NA (NA, NA)
PI3K+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.015 (0.008, 0.019) 0.012 (0.007, 0.019) 0.013 (0.008, 0.02) 0.013 (0, 0.016) NA (NA, NA) 0.005 (0, 0.035) 0.011 (0, 0.024) NA (NA, NA)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
all TC1 time 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47) 39 (23, 47)
all TC1 n 59 (36, 72) 16 (8, 21) 3 (2, 4) 16 (9, 28) 23 (12, 29) 13 (9, 17) 11 (7, 15) 9 (5, 14) 11 (6, 16) 0 (0, 0) 12 (6, 15) 2 (1, 4) 0 (0, 1) 2 (1, 4) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.32 (0.14, 0.43) 0.31 (0.17, 0.38) 0.38 (0.27, 0.46) 0.43 (0.33, 0.45) 0.36 (0.23, 0.47) 0.3 (0.1, 0.4) 0.41 (0.26, 0.48) 0.38 (0.17, 0.5) 0.42 (0.13, 0.49) NA (NA, NA) 0.41 (0.19, 0.45) 0.45 (0.35, 0.49) 0.46 (0.44, 0.49) 0.48 (0.29, 0.49) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.023 (0.021, 0.029) 0.029 (0.021, 0.035) 0.041 (0.03, 0.055) 0.023 (0.02, 0.029) 0.025 (0.021, 0.047) 0.028 (0.024, 0.039) 0.023 (0.019, 0.033) 0.028 (0.015, 0.044) 0.027 (0.018, 0.032) NA (NA, NA) 0.029 (0.022, 0.035) 0.036 (0.015, 0.885) 0.082 (0.016, 0.244) 0.03 (0.007, 0.167) NA (NA, NA) NA (NA, NA)
all TC2 count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
all TC2 time 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50) 30 (24, 50)
all TC2 n 49 (40, 74) 13 (10, 15) 5 (0, 10) 19 (9, 29) 23 (16, 32) 10 (7, 20) 12 (7, 19) 8 (4, 15) 14 (5, 20) 0 (0, 0) 8 (4, 14) 2 (0, 4) 0 (0, 2) 2 (1, 7) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.21 (0.07, 0.49) 0.36 (0.11, 0.49) 0.44 (0.29, 0.46) 0.27 (0.16, 0.44) 0.3 (0.17, 0.38) 0.35 (0.08, 0.48) 0.38 (0.22, 0.5) 0.46 (0.31, 0.49) 0.28 (0.16, 0.45) NA (NA, NA) 0.28 (0.13, 0.47) 0.48 (0.36, 0.49) 0.46 (0.45, 0.49) 0.43 (0.32, 0.49) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.025 (0.02, 0.028) 0.032 (0.019, 0.053) 0.032 (0.024, 0.076) 0.03 (0.02, 0.041) 0.03 (0.022, 0.041) 0.034 (0.019, 0.042) 0.027 (0.018, 0.038) 0.023 (0.009, 0.037) 0.031 (0.024, 0.051) NA (NA, NA) 0.037 (0.028, 0.066) 0.026 (0.009, 0.177) 0.013 (0, 0.247) 0.039 (0, 0.233) NA (NA, NA) NA (NA, NA)
all TC4 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC4 time 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40)
all TC4 n 64 (64, 64) 15 (15, 15) 2 (2, 2) 17 (17, 17) 24 (24, 24) 11 (11, 11) 8 (8, 8) 7 (7, 7) 16 (16, 16) 0 (0, 0) 7 (7, 7) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.05 (0.05, 0.05) 0.17 (0.17, 0.17) 0.45 (0.45, 0.45) 0.46 (0.46, 0.46) 0.41 (0.41, 0.41) 0.38 (0.38, 0.38) 0.28 (0.28, 0.28) 0.45 (0.45, 0.45) 0.45 (0.45, 0.45) NA (NA, NA) 0.28 (0.28, 0.28) NA (NA, NA) NA (NA, NA) 0.45 (0.45, 0.45) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.028 (0.028, 0.028) 0.036 (0.036, 0.036) 0.086 (0.086, 0.086) 0.02 (0.02, 0.02) 0.025 (0.025, 0.025) 0.024 (0.024, 0.024) 0.034 (0.034, 0.034) 0.021 (0.021, 0.021) 0.022 (0.022, 0.022) NA (NA, NA) 0.037 (0.037, 0.037) NA (NA, NA) NA (NA, NA) 0.119 (0.119, 0.119) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 29 29 29 29 29 29 29 29
HRD+ TC1 time 57 (52, 59) 57 (52, 59) 57 (52, 59) 57 (52, 59) 57 (52, 59) 57 (52, 59) 57 (52, 59) 57 (52, 59)
HRD+ TC1 n 25 (18, 30) 0 (0, 0) 18 (14, 23) 4 (1, 8) 0 (0, 2) 6 (3, 10) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.2 (0.11, 0.36) NA (NA, NA) 0.24 (0.05, 0.44) 0.44 (0.34, 0.49) 0.48 (0.44, 0.49) 0.38 (0.22, 0.48) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.027 (0.023, 0.035) NA (NA, NA) 0.028 (0.022, 0.042) 0.033 (0.02, 0.063) 0.04 (0, 0.121) 0.03 (0.02, 0.056) NA (NA, NA) 0.271 (0.271, 0.271)
HRD+ TC2 count 23 23 23 23 23 23 23 23
HRD+ TC2 time 55 (53, 60) 55 (53, 60) 55 (53, 60) 55 (53, 60) 55 (53, 60) 55 (53, 60) 55 (53, 60) 55 (53, 60)
HRD+ TC2 n 23 (17, 30) 0 (0, 0) 19 (14, 25) 4 (2, 6) 0 (0, 1) 5 (3, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.29 (0.15, 0.47) NA (NA, NA) 0.22 (0.09, 0.48) 0.44 (0.3, 0.49) 0.46 (0.44, 0.49) 0.35 (0.23, 0.47) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.026 (0.02, 0.035) 0 (0, 0) 0.028 (0.019, 0.038) 0.028 (0.017, 0.082) 0.058 (0, 0.268) 0.031 (0.019, 0.057) NA (NA, NA) 0 (0, 0)
HRD+ TC4 count 5 5 5 5 5 5 5 5
HRD+ TC4 time 54 (53, 58) 54 (53, 58) 54 (53, 58) 54 (53, 58) 54 (53, 58) 54 (53, 58) 54 (53, 58) 54 (53, 58)
HRD+ TC4 n 24 (18, 27) 0 (0, 0) 21 (15, 28) 3 (2, 6) 0 (0, 2) 6 (2, 10) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.2 (0.09, 0.44) NA (NA, NA) 0.4 (0.19, 0.5) 0.45 (0.42, 0.49) NA (NA, NA) 0.38 (0.23, 0.47) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.03 (0.021, 0.036) NA (NA, NA) 0.023 (0.015, 0.03) 0.04 (0.019, 0.067) 0.028 (0.028, 0.028) 0.028 (0.019, 0.041) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 126 126 126 126 126 126 126 126
TP53+ TC1 time 34 (24, 50) 34 (24, 50) 34 (24, 50) 34 (24, 50) 34 (24, 50) 34 (24, 50) 34 (24, 50) 34 (24, 50)
TP53+ TC1 n 23 (16, 38) 14 (9, 23) 14 (9, 22) 11 (7, 17) 0 (0, 2) 3 (0, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.31 (0.08, 0.46) 0.37 (0.17, 0.48) 0.39 (0.16, 0.48) 0.38 (0.18, 0.48) 0.45 (0.41, 0.48) 0.46 (0.38, 0.5) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.027 (0.019, 0.037) 0.026 (0.019, 0.041) 0.027 (0.019, 0.04) 0.028 (0.019, 0.042) 0.039 (0, 0.347) 0.029 (0, 0.091) 0 (0, 0) NA (NA, NA)
TP53+ TC2 count 132 132 132 132 132 132 132 132
TP53+ TC2 time 38 (25, 53) 38 (25, 53) 38 (25, 53) 38 (25, 53) 38 (25, 53) 38 (25, 53) 38 (25, 53) 38 (25, 53)
TP53+ TC2 n 25 (16, 38) 16 (10, 27) 15 (9, 24) 12 (7, 20) 0 (0, 1) 3 (0, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.35 (0.11, 0.48) 0.37 (0.13, 0.48) 0.34 (0.14, 0.48) 0.38 (0.11, 0.48) 0.45 (0.41, 0.49) 0.44 (0.31, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.025 (0.02, 0.033) 0.026 (0.018, 0.037) 0.027 (0.02, 0.041) 0.027 (0.018, 0.044) 0.027 (0, 0.234) 0.033 (0, 0.1) 0 (0, 0) 0 (0, 0)
TP53+ TC3 count 26 26 26 26 26 26 26 26
TP53+ TC3 time 37 (26, 48) 37 (26, 48) 37 (26, 48) 37 (26, 48) 37 (26, 48) 37 (26, 48) 37 (26, 48) 37 (26, 48)
TP53+ TC3 n 22 (16, 36) 17 (10, 30) 14 (8, 22) 11 (6, 18) 0 (0, 1) 3 (0, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.32 (0.18, 0.45) 0.41 (0.3, 0.47) 0.39 (0.2, 0.49) 0.38 (0.24, 0.46) 0.48 (0.48, 0.49) 0.47 (0.41, 0.5) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.027 (0.019, 0.037) 0.024 (0.02, 0.038) 0.023 (0.019, 0.036) 0.026 (0.021, 0.038) 0 (0, 0) 0.017 (0.001, 0.052) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 43 43 43 43 43 43 43 43
TP53+ TC4 time 36 (26, 52) 36 (26, 52) 36 (26, 52) 36 (26, 52) 36 (26, 52) 36 (26, 52) 36 (26, 52) 36 (26, 52)
TP53+ TC4 n 25 (17, 38) 16 (9, 28) 15 (8, 22) 11 (6, 20) 0 (0, 1) 3 (0, 4) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.36 (0.17, 0.47) 0.36 (0.16, 0.48) 0.38 (0.19, 0.48) 0.41 (0.19, 0.49) 0.48 (0.47, 0.48) 0.45 (0.38, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.024 (0.02, 0.032) 0.027 (0.02, 0.037) 0.027 (0.019, 0.036) 0.025 (0.018, 0.033) 0.011 (0, 0.073) 0.032 (0.016, 0.096) NA (NA, NA) 0 (0, 0)
TEfus+ TC1 count 92 92 92 92 92 92 92 92
TEfus+ TC1 time 41 (30, 55) 41 (30, 55) 41 (30, 55) 41 (30, 55) 41 (30, 55) 41 (30, 55) 41 (30, 55) 41 (30, 55)
TEfus+ TC1 n 4 (2, 8) 22 (13, 33) 15 (10, 24) 11 (6, 18) 10 (5, 18) 2 (1, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.43 (0.32, 0.49) 0.3 (0.07, 0.46) 0.34 (0.16, 0.46) 0.34 (0.15, 0.47) 0.37 (0.21, 0.47) 0.46 (0.35, 0.5) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.031 (0.02, 0.075) 0.027 (0.021, 0.036) 0.027 (0.02, 0.036) 0.029 (0.021, 0.048) 0.028 (0.019, 0.041) 0.03 (0, 0.137) 0.06 (0.06, 0.06) 0.271 (0.271, 0.271)
TEfus+ TC2 count 93 93 93 93 93 93 93 93
TEfus+ TC2 time 39 (30, 54) 39 (30, 54) 39 (30, 54) 39 (30, 54) 39 (30, 54) 39 (30, 54) 39 (30, 54) 39 (30, 54)
TEfus+ TC2 n 5 (2, 9) 21 (16, 32) 15 (9, 24) 11 (7, 19) 9 (5, 16) 3 (0, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.43 (0.3, 0.49) 0.28 (0.1, 0.47) 0.34 (0.1, 0.48) 0.34 (0.13, 0.46) 0.37 (0.15, 0.49) 0.45 (0.35, 0.49) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.033 (0.018, 0.065) 0.026 (0.02, 0.036) 0.027 (0.018, 0.039) 0.029 (0.02, 0.046) 0.03 (0.018, 0.049) 0.035 (0.014, 0.111) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 count 2 2 2 2 2 2 2 2
TEfus+ TC3 time 41 (35, 47) 41 (35, 47) 41 (35, 47) 41 (35, 47) 41 (35, 47) 41 (35, 47) 41 (35, 47) 41 (35, 47)
TEfus+ TC3 n 4 (3, 4) 22 (19, 24) 16 (14, 18) 10 (5, 14) 10 (9, 11) 5 (5, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.34 (0.23, 0.44) 0.44 (0.4, 0.48) 0.39 (0.36, 0.43) 0.37 (0.27, 0.47) 0.42 (0.42, 0.43) 0.41 (0.38, 0.44) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.034 (0.034, 0.035) 0.023 (0.022, 0.024) 0.024 (0.023, 0.024) 0.024 (0.016, 0.032) 0.015 (0.014, 0.016) 0.031 (0.023, 0.039) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 18 18 18 18 18 18 18 18
TEfus+ TC4 time 37 (26, 47) 37 (26, 47) 37 (26, 47) 37 (26, 47) 37 (26, 47) 37 (26, 47) 37 (26, 47) 37 (26, 47)
TEfus+ TC4 n 4 (2, 7) 18 (14, 27) 14 (9, 24) 11 (6, 15) 10 (6, 14) 2 (0, 3) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.44 (0.39, 0.48) 0.33 (0.13, 0.42) 0.41 (0.28, 0.48) 0.36 (0.22, 0.46) 0.37 (0.23, 0.44) 0.42 (0.38, 0.48) NA (NA, NA) 0.47 (0.47, 0.47)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.029 (0.017, 0.052) 0.026 (0.018, 0.032) 0.023 (0.014, 0.029) 0.028 (0.02, 0.038) 0.031 (0.018, 0.046) 0.071 (0.011, 0.164) NA (NA, NA) 0.052 (0.01, 0.093)
PI3K+ TC1 count 97 97 97 97 97 97 97 97
PI3K+ TC1 time 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56)
PI3K+ TC1 n 16 (9, 22) 22 (13, 33) 16 (11, 29) 11 (7, 19) 0 (0, 0) 2 (0, 5) 3 (1, 7) 0 (0, 0)
PI3K+ TC1 post_p 0.36 (0.13, 0.47) 0.34 (0.11, 0.45) 0.34 (0.11, 0.47) 0.36 (0.16, 0.48) NA (NA, NA) 0.45 (0.34, 0.49) 0.45 (0.34, 0.48) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.028 (0.019, 0.039) 0.026 (0.019, 0.037) 0.027 (0.019, 0.038) 0.027 (0.02, 0.038) 0 (0, 0) 0.031 (0.002, 0.104) 0.033 (0.013, 0.084) 0 (0, 0.217)
PI3K+ TC2 count 93 93 93 93 93 93 93 93
PI3K+ TC2 time 40 (27, 55) 40 (27, 55) 40 (27, 55) 40 (27, 55) 40 (27, 55) 40 (27, 55) 40 (27, 55) 40 (27, 55)
PI3K+ TC2 n 14 (9, 23) 21 (15, 32) 17 (10, 27) 13 (7, 21) 0 (0, 0) 2 (0, 5) 3 (1, 7) 0 (0, 0)
PI3K+ TC2 post_p 0.34 (0.15, 0.47) 0.32 (0.1, 0.47) 0.37 (0.12, 0.48) 0.35 (0.11, 0.47) NA (NA, NA) 0.46 (0.38, 0.49) 0.43 (0.31, 0.49) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.028 (0.019, 0.049) 0.026 (0.02, 0.034) 0.026 (0.02, 0.039) 0.027 (0.019, 0.041) NA (NA, NA) 0.033 (0.011, 0.109) 0.032 (0.013, 0.073) 0.02 (0.004, 0.035)
PI3K+ TC3 count 13 13 13 13 13 13 13 13
PI3K+ TC3 time 37 (25, 47) 37 (25, 47) 37 (25, 47) 37 (25, 47) 37 (25, 47) 37 (25, 47) 37 (25, 47) 37 (25, 47)
PI3K+ TC3 n 14 (9, 19) 21 (10, 31) 15 (11, 21) 11 (9, 16) 0 (0, 0) 2 (0, 4) 2 (0, 5) 0 (0, 0)
PI3K+ TC3 post_p 0.36 (0.2, 0.46) 0.34 (0.2, 0.47) 0.41 (0.2, 0.47) 0.33 (0.19, 0.46) NA (NA, NA) 0.46 (0.41, 0.5) 0.49 (0.45, 0.5) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.026 (0.019, 0.037) 0.025 (0.018, 0.032) 0.027 (0.02, 0.032) 0.029 (0.022, 0.034) NA (NA, NA) 0.02 (0, 0.067) 0.02 (0, 0.184) NA (NA, NA)
PI3K+ TC4 count 30 30 30 30 30 30 30 30
PI3K+ TC4 time 35 (27, 50) 35 (27, 50) 35 (27, 50) 35 (27, 50) 35 (27, 50) 35 (27, 50) 35 (27, 50) 35 (27, 50)
PI3K+ TC4 n 14 (10, 21) 20 (15, 30) 15 (10, 27) 10 (5, 21) 0 (0, 0) 2 (0, 5) 2 (0, 5) 0 (0, 0)
PI3K+ TC4 post_p 0.41 (0.22, 0.49) 0.37 (0.16, 0.46) 0.37 (0.12, 0.48) 0.41 (0.29, 0.48) NA (NA, NA) 0.45 (0.37, 0.5) 0.46 (0.34, 0.5) 0.48 (0.48, 0.48)
PI3K+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.023 (0.016, 0.031) 0.025 (0.017, 0.034) 0.025 (0.018, 0.036) 0.027 (0.018, 0.04) NA (NA, NA) 0.034 (0.012, 0.064) 0.03 (0.012, 0.07) 0.085 (0.07, 0.1)