Equal randomization: TC3 more effective in the HRD+ biomarker signature (cfr scen 4)
| signature | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.022, shape = 1.3 | scale = 0.024, shape = 1.3 |
| all | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 41.8, median = 34.2 | mean = 39, median = 31.9 |
| all | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1.07, hr = 0.91 | af = 1, hr = 1 |
| HRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| HRD+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| HRD+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.023, shape = 1.3 | scale = 0.024, shape = 1.3 |
| TP53+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39.9, median = 32.6 | mean = 39, median = 31.9 |
| TP53+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1.02, hr = 0.97 | af = 1, hr = 1 |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.022, shape = 1.3 | scale = 0.024, shape = 1.3 |
| TEfus+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 42.7, median = 34.8 | mean = 39, median = 31.9 |
| TEfus+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1.09, hr = 0.89 | af = 1, hr = 1 |
| PI3K+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.023, shape = 1.3 | scale = 0.024, shape = 1.3 |
| PI3K+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 40.5, median = 33.1 | mean = 39, median = 31.9 |
| PI3K+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1.04, hr = 0.95 | af = 1, hr = 1 |
| subtype | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| —- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| —- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| —+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| —+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| —+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| –+- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| –+- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| –++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| –++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| –++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+– | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+– | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+– | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+-+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+-+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+-+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| -++- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -++- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -++- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| +— | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +— | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| +— | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| +–+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +–+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| +–+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| +-+- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +-+- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| +-+- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| +-++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +-++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| +-++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| ++– | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++– | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| ++– | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| ++-+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++-+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| ++-+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| +++- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +++- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| +++- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| ++++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| ++++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
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| Characteristics | Overall | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| Error signature | 0.478 | 0.028 | 0.05 | 0.304 | 0.194 |
| Error subgroup | 0.498 | 0.028 | 0.05 | 0.338 | 0.194 |
| Power signature | 0.166 | 0.000 | 0.00 | 0.166 | 0.000 |
| Power subgroup | 0.470 | 0.000 | 0.00 | 0.470 | 0.000 |
| signature | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 3 | 9 | 75 | 20 |
| all | futility | 0 | 9 | 10 | 0 | 1 |
| all | max_n | 0 | 0 | 0 | 0 | 0 |
| all | n | 588 (564, 616) | 305 (237, 367) | 302 (238, 367) | 308 (215, 356) | 314 (254, 379) |
| all | n_unique | 588 (564, 616) | 305 (237, 367) | 302 (238, 367) | 308 (215, 356) | 314 (254, 379) |
| all | time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (44, 60) | 60 (60, 60) |
| all | time_stop | NA (NA, NA) | 34 (11, 47) | 29 (11, 52) | 34 (12, 56) | 26 (12, 51) |
| all | post_p | NA (NA, NA) | 0.29 (0.05, 0.81) | 0.36 (0.04, 0.8) | 0.99 (0.83, 1) | 0.87 (0.39, 1) |
| all | rate | 0.023 (0.022, 0.025) | 0.025 (0.023, 0.027) | 0.024 (0.022, 0.027) | 0.019 (0.017, 0.021) | 0.021 (0.019, 0.023) |
| HRD+ | graduation | 0 | 1 | 2 | 83 | 8 |
| HRD+ | futility | 0 | 29 | 23 | 0 | 5 |
| HRD+ | max_n | 0 | 0 | 0 | 0 | 0 |
| HRD+ | n | 86 (73, 98) | 44 (34, 55) | 44 (32, 54) | 44 (28, 51) | 45 (35, 57) |
| HRD+ | n_unique | 86 (73, 98) | 44 (34, 55) | 44 (32, 54) | 44 (28, 51) | 45 (35, 57) |
| HRD+ | time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (58, 60) | 60 (60, 60) |
| HRD+ | time_stop | NA (NA, NA) | 57 (52, 59) | 56 (53, 60) | 56 (47, 60) | 54 (51, 57) |
| HRD+ | post_p | NA (NA, NA) | 0.37 (0.08, 0.82) | 0.37 (0.08, 0.82) | 1 (0.97, 1) | 0.6 (0.2, 0.92) |
| HRD+ | rate | 0.023 (0.02, 0.028) | 0.025 (0.019, 0.031) | 0.024 (0.018, 0.031) | 0.009 (0.006, 0.013) | 0.021 (0.016, 0.027) |
| TP53+ | graduation | 0 | 4 | 7 | 41 | 36 |
| TP53+ | futility | 0 | 126 | 132 | 26 | 43 |
| TP53+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TP53+ | n | 219 (201, 237) | 114 (56, 147) | 112 (57, 151) | 116 (59, 151) | 119 (75, 158) |
| TP53+ | n_unique | 219 (201, 237) | 114 (56, 147) | 112 (57, 151) | 116 (59, 151) | 119 (75, 158) |
| TP53+ | time_trial | 60 (60, 60) | 60 (31, 60) | 60 (31, 60) | 60 (49, 60) | 60 (42, 60) |
| TP53+ | time_stop | NA (NA, NA) | 34 (24, 50) | 38 (25, 53) | 38 (28, 56) | 39 (27, 55) |
| TP53+ | post_p | NA (NA, NA) | 0.36 (0.07, 0.82) | 0.38 (0.06, 0.82) | 0.81 (0.38, 0.98) | 0.76 (0.28, 0.98) |
| TP53+ | rate | 0.023 (0.021, 0.026) | 0.025 (0.021, 0.03) | 0.025 (0.021, 0.029) | 0.02 (0.017, 0.024) | 0.021 (0.017, 0.025) |
| TEfus+ | graduation | 0 | 1 | 5 | 66 | 26 |
| TEfus+ | futility | 0 | 92 | 93 | 2 | 18 |
| TEfus+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TEfus+ | n | 193 (174, 208) | 100 (60, 130) | 98 (58, 127) | 100 (56, 127) | 104 (69, 136) |
| TEfus+ | n_unique | 193 (174, 208) | 100 (60, 130) | 98 (58, 127) | 100 (56, 127) | 104 (69, 136) |
| TEfus+ | time_trial | 60 (60, 60) | 60 (41, 60) | 60 (39, 60) | 60 (49, 60) | 60 (60, 60) |
| TEfus+ | time_stop | NA (NA, NA) | 41 (30, 55) | 39 (30, 53) | 41 (31, 57) | 40 (29, 54) |
| TEfus+ | post_p | NA (NA, NA) | 0.39 (0.05, 0.84) | 0.41 (0.06, 0.82) | 0.92 (0.57, 1) | 0.74 (0.33, 0.98) |
| TEfus+ | rate | 0.024 (0.021, 0.026) | 0.025 (0.021, 0.03) | 0.025 (0.021, 0.03) | 0.018 (0.015, 0.022) | 0.021 (0.017, 0.025) |
| PI3K+ | graduation | 0 | 5 | 6 | 45 | 21 |
| PI3K+ | futility | 0 | 97 | 93 | 13 | 30 |
| PI3K+ | max_n | 0 | 0 | 0 | 0 | 0 |
| PI3K+ | n | 206 (188, 226) | 107 (67, 138) | 106 (64, 140) | 108 (57, 139) | 115 (76, 148) |
| PI3K+ | n_unique | 206 (188, 226) | 107 (67, 138) | 106 (64, 140) | 108 (57, 139) | 115 (76, 148) |
| PI3K+ | time_trial | 60 (60, 60) | 60 (40, 60) | 60 (41, 60) | 60 (57, 60) | 60 (60, 60) |
| PI3K+ | time_stop | NA (NA, NA) | 40 (28, 56) | 41 (27, 55) | 42 (28, 58) | 38 (29, 52) |
| PI3K+ | post_p | NA (NA, NA) | 0.39 (0.06, 0.81) | 0.38 (0.07, 0.81) | 0.83 (0.39, 0.99) | 0.76 (0.25, 0.98) |
| PI3K+ | rate | 0.024 (0.021, 0.026) | 0.025 (0.021, 0.03) | 0.025 (0.021, 0.029) | 0.02 (0.017, 0.024) | 0.021 (0.017, 0.026) |
| subtype | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 3 | 9 | 75 | 20 |
| —- | futility | 0 | 9 | 10 | 0 | 1 |
| —- | max_n | 0 | 0 | 0 | 0 | 0 |
| —- | n | 176 (161, 194) | 92 (78, 109) | 93 (79, 107) | 91 (65, 106) | 91 (77, 107) |
| —- | n_unique | 176 (161, 194) | 92 (78, 109) | 93 (79, 107) | 91 (65, 106) | 91 (77, 107) |
| —- | post_p | NA (NA, NA) | 0.41 (0.07, 0.83) | 0.38 (0.07, 0.83) | 0.74 (0.27, 0.97) | 0.74 (0.29, 0.96) |
| —- | rate | 0.023 (0.021, 0.026) | 0.025 (0.02, 0.029) | 0.025 (0.02, 0.029) | 0.021 (0.017, 0.025) | 0.021 (0.017, 0.025) |
| —+ | graduation | 0 | 8 | 13 | 109 | 40 |
| —+ | futility | 0 | 99 | 95 | 13 | 30 |
| —+ | max_n | 0 | 0 | 0 | 0 | 0 |
| —+ | n | 42 (33, 51) | 22 (13, 30) | 22 (13, 29) | 22 (12, 29) | 23 (14, 31) |
| —+ | n_unique | 42 (33, 51) | 22 (13, 30) | 22 (13, 29) | 22 (12, 29) | 23 (14, 31) |
| —+ | post_p | NA (NA, NA) | 0.46 (0.1, 0.81) | 0.47 (0.12, 0.87) | 0.59 (0.2, 0.91) | 0.62 (0.23, 0.92) |
| —+ | rate | 0.023 (0.017, 0.03) | 0.025 (0.017, 0.037) | 0.024 (0.016, 0.035) | 0.022 (0.014, 0.032) | 0.021 (0.014, 0.03) |
| –+- | graduation | 0 | 4 | 14 | 129 | 46 |
| –+- | futility | 0 | 95 | 97 | 2 | 19 |
| –+- | max_n | 0 | 0 | 0 | 0 | 0 |
| –+- | n | 13 (9, 19) | 7 (3, 11) | 7 (3, 11) | 6 (2, 11) | 7 (3, 11) |
| –+- | n_unique | 13 (9, 19) | 7 (3, 11) | 7 (3, 11) | 6 (2, 11) | 7 (3, 11) |
| –+- | post_p | NA (NA, NA) | 0.47 (0.18, 0.75) | 0.48 (0.21, 0.76) | 0.56 (0.28, 0.79) | 0.53 (0.27, 0.82) |
| –+- | rate | 0.024 (0.014, 0.037) | 0.025 (0.011, 0.05) | 0.024 (0.012, 0.047) | 0.02 (0.008, 0.041) | 0.021 (0.008, 0.042) |
| –++ | graduation | 0 | 8 | 18 | 149 | 63 |
| –++ | futility | 0 | 153 | 154 | 15 | 43 |
| –++ | max_n | 0 | 0 | 0 | 0 | 0 |
| –++ | n | 62 (52, 72) | 31 (18, 45) | 31 (18, 44) | 31 (16, 43) | 33 (20, 47) |
| –++ | n_unique | 62 (52, 72) | 31 (18, 45) | 31 (18, 44) | 31 (16, 43) | 33 (20, 47) |
| –++ | post_p | NA (NA, NA) | 0.44 (0.1, 0.81) | 0.43 (0.09, 0.82) | 0.64 (0.24, 0.93) | 0.62 (0.22, 0.93) |
| –++ | rate | 0.023 (0.019, 0.029) | 0.025 (0.019, 0.034) | 0.025 (0.018, 0.035) | 0.021 (0.015, 0.028) | 0.021 (0.015, 0.029) |
| -+– | graduation | 0 | 7 | 15 | 104 | 55 |
| -+– | futility | 0 | 129 | 133 | 26 | 43 |
| -+– | max_n | 0 | 0 | 0 | 0 | 0 |
| -+– | n | 76 (66, 87) | 39 (21, 54) | 39 (21, 53) | 40 (21, 54) | 41 (25, 54) |
| -+– | n_unique | 76 (66, 87) | 39 (21, 54) | 39 (21, 53) | 40 (21, 54) | 41 (25, 54) |
| -+– | post_p | NA (NA, NA) | 0.41 (0.07, 0.84) | 0.45 (0.11, 0.83) | 0.66 (0.22, 0.92) | 0.64 (0.2, 0.95) |
| -+– | rate | 0.023 (0.019, 0.028) | 0.025 (0.018, 0.033) | 0.024 (0.019, 0.032) | 0.021 (0.016, 0.028) | 0.021 (0.015, 0.029) |
| -+-+ | graduation | 0 | 12 | 18 | 132 | 69 |
| -+-+ | futility | 0 | 172 | 173 | 36 | 68 |
| -+-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+-+ | n | 51 (41, 61) | 26 (12, 36) | 26 (13, 37) | 27 (12, 38) | 28 (14, 41) |
| -+-+ | n_unique | 51 (41, 61) | 26 (12, 36) | 26 (13, 37) | 27 (12, 38) | 28 (14, 41) |
| -+-+ | post_p | NA (NA, NA) | 0.44 (0.1, 0.83) | 0.42 (0.11, 0.81) | 0.58 (0.21, 0.91) | 0.6 (0.21, 0.92) |
| -+-+ | rate | 0.023 (0.018, 0.029) | 0.025 (0.017, 0.034) | 0.025 (0.017, 0.034) | 0.022 (0.014, 0.03) | 0.021 (0.014, 0.03) |
| -++- | graduation | 0 | 8 | 19 | 150 | 78 |
| -++- | futility | 0 | 180 | 183 | 28 | 57 |
| -++- | max_n | 0 | 0 | 0 | 0 | 0 |
| -++- | n | 45 (38, 54) | 23 (11, 34) | 23 (11, 34) | 23 (12, 35) | 25 (13, 37) |
| -++- | n_unique | 45 (38, 54) | 23 (11, 34) | 23 (11, 34) | 23 (12, 35) | 25 (13, 37) |
| -++- | post_p | NA (NA, NA) | 0.45 (0.11, 0.83) | 0.45 (0.11, 0.82) | 0.63 (0.25, 0.91) | 0.62 (0.22, 0.92) |
| -++- | rate | 0.024 (0.018, 0.03) | 0.024 (0.017, 0.036) | 0.025 (0.016, 0.037) | 0.021 (0.013, 0.03) | 0.021 (0.014, 0.03) |
| -+++ | graduation | 0 | 12 | 22 | 169 | 91 |
| -+++ | futility | 0 | 210 | 213 | 38 | 79 |
| -+++ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+++ | n | 36 (29, 43) | 17 (8, 28) | 17 (8, 28) | 19 (8, 29) | 20 (10, 31) |
| -+++ | n_unique | 36 (29, 43) | 17 (8, 28) | 17 (8, 28) | 19 (8, 29) | 20 (10, 31) |
| -+++ | post_p | NA (NA, NA) | 0.43 (0.12, 0.81) | 0.45 (0.13, 0.81) | 0.62 (0.25, 0.9) | 0.63 (0.25, 0.91) |
| -+++ | rate | 0.024 (0.018, 0.031) | 0.026 (0.017, 0.038) | 0.025 (0.017, 0.037) | 0.021 (0.013, 0.032) | 0.021 (0.013, 0.031) |
| +— | graduation | 0 | 4 | 11 | 154 | 27 |
| +— | futility | 0 | 38 | 33 | 0 | 6 |
| +— | max_n | 0 | 0 | 0 | 0 | 0 |
| +— | n | 40 (32, 49) | 21 (15, 28) | 21 (14, 27) | 20 (12, 27) | 21 (15, 28) |
| +— | n_unique | 40 (32, 49) | 21 (15, 28) | 21 (14, 27) | 20 (12, 27) | 21 (15, 28) |
| +— | post_p | NA (NA, NA) | 0.42 (0.1, 0.8) | 0.4 (0.1, 0.78) | 0.96 (0.78, 1) | 0.53 (0.17, 0.87) |
| +— | rate | 0.023 (0.017, 0.03) | 0.024 (0.016, 0.034) | 0.024 (0.016, 0.035) | 0.009 (0.004, 0.015) | 0.022 (0.014, 0.031) |
| +–+ | graduation | 0 | 9 | 15 | 181 | 47 |
| +–+ | futility | 0 | 119 | 111 | 13 | 34 |
| +–+ | max_n | 0 | 0 | 0 | 0 | 0 |
| +–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.51 (0.51, 0.51) |
| +–+ | rate | 0.038 (0.007, 0.053) | 0 (0, 0.041) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.16) |
| +-+- | graduation | 0 | 5 | 16 | 204 | 53 |
| +-+- | futility | 0 | 120 | 117 | 2 | 24 |
| +-+- | max_n | 0 | 0 | 0 | 0 | 0 |
| +-+- | n | 28 (21, 36) | 15 (8, 21) | 14 (8, 21) | 14 (7, 20) | 15 (9, 21) |
| +-+- | n_unique | 28 (21, 36) | 15 (8, 21) | 14 (8, 21) | 14 (7, 20) | 15 (9, 21) |
| +-+- | post_p | NA (NA, NA) | 0.42 (0.1, 0.78) | 0.41 (0.13, 0.77) | 0.93 (0.67, 0.99) | 0.54 (0.19, 0.87) |
| +-+- | rate | 0.024 (0.016, 0.033) | 0.024 (0.016, 0.038) | 0.025 (0.014, 0.038) | 0.008 (0.003, 0.016) | 0.021 (0.012, 0.032) |
| +-++ | graduation | 0 | 9 | 20 | 218 | 70 |
| +-++ | futility | 0 | 172 | 168 | 15 | 47 |
| +-++ | max_n | 0 | 0 | 0 | 0 | 0 |
| +-++ | n | 7 (3, 11) | 3 (1, 7) | 3 (1, 6) | 3 (1, 6) | 4 (1, 7) |
| +-++ | n_unique | 7 (3, 11) | 3 (1, 7) | 3 (1, 6) | 3 (1, 6) | 4 (1, 7) |
| +-++ | post_p | NA (NA, NA) | 0.47 (0.3, 0.65) | 0.48 (0.3, 0.64) | 0.59 (0.43, 0.82) | 0.5 (0.33, 0.67) |
| +-++ | rate | 0.024 (0.008, 0.045) | 0.024 (0, 0.064) | 0.024 (0, 0.063) | 0.008 (0, 0.034) | 0.022 (0, 0.052) |
| ++– | graduation | 0 | 8 | 17 | 178 | 59 |
| ++– | futility | 0 | 151 | 148 | 25 | 48 |
| ++– | max_n | 0 | 0 | 0 | 0 | 0 |
| ++– | n | 1 (0, 3) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 1 (0, 2) |
| ++– | n_unique | 1 (0, 3) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 1 (0, 2) |
| ++– | post_p | NA (NA, NA) | 0.48 (0.42, 0.56) | 0.48 (0.42, 0.56) | 0.53 (0.46, 0.58) | 0.5 (0.43, 0.56) |
| ++– | rate | 0.019 (0, 0.071) | 0.024 (0, 0.106) | 0.024 (0, 0.122) | 0 (0, 0.039) | 0.014 (0, 0.094) |
| ++-+ | graduation | 0 | 13 | 20 | 201 | 73 |
| ++-+ | futility | 0 | 188 | 184 | 35 | 72 |
| ++-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++-+ | n | 9 (5, 13) | 4 (1, 8) | 4 (1, 8) | 4 (1, 8) | 5 (2, 9) |
| ++-+ | n_unique | 9 (5, 13) | 4 (1, 8) | 4 (1, 8) | 4 (1, 8) | 5 (2, 9) |
| ++-+ | post_p | NA (NA, NA) | 0.46 (0.27, 0.68) | 0.46 (0.22, 0.71) | 0.65 (0.47, 0.86) | 0.5 (0.29, 0.71) |
| ++-+ | rate | 0.023 (0.011, 0.04) | 0.024 (0.008, 0.054) | 0.025 (0.006, 0.055) | 0.009 (0, 0.025) | 0.021 (0.006, 0.056) |
| +++- | graduation | 0 | 9 | 21 | 221 | 82 |
| +++- | futility | 0 | 199 | 195 | 27 | 62 |
| +++- | max_n | 0 | 0 | 0 | 0 | 0 |
| +++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| +++- | rate | 0.064 (0, 0.278) | 0.055 (0.051, 0.059) | 0.018 (0, 0.051) | 0.021 (0.021, 0.021) | 0 (0, 0) |
| ++++ | graduation | 0 | 13 | 24 | 235 | 95 |
| ++++ | futility | 0 | 225 | 222 | 37 | 83 |
| ++++ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | post_p | NA (NA, NA) | 0.48 (0.48, 0.48) | NA (NA, NA) | 0.51 (0.51, 0.51) | 0.48 (0.46, 0.5) |
| ++++ | rate | 0 (0, 0.069) | 0.044 (0, 0.261) | 0.012 (0, 0.034) | 0 (0, 0.039) | 0 (0, 0.111) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates